Non-Hodgkin Lymphoma 20 percent more likely if low UV – meta-analysis

Created April 2019

Vitamin D status and risk of non-Hodgkin lymphoma: An updated meta-analysis

Hye Yin Park , Yun-Chul Hong, Kyoungho Lee, Jaewoo Koh, https://doi.org/10.1371/journal.pone.0216284

* Hodgkin’s lymphoma and Vitamin D Receptor - June 2012 * Vitamin D Insufficiency and Prognosis in Non-Hodgkins Lymphoma * Lymphoma, leukemia etc, survival poor if low vitamin D – meta-analysis March 2015 * Lymphoid cancer deaths cut in half with 400 IU of vitamin D and 1 gram of Calcium (WHI) – RCT Nov 2017 Sun/UVB is perhaps better than Vitamin D for preventing some Cancers 1. Items in both categories Cancer and UV: {category} --- 1. Other diseases appear to be prevented/treated by UV, perhaps better than Vitamin D: MS is an example The articles in both of the categories MS and UV are: {category}

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This meta-analysis aimed to extensively investigate the association between various measures of vitamin D status and non-Hodgkin lymphoma (NHL) and its subtypes.

Methods: We searched MEDLINE (PubMed), Embase, and the Cochrane Library in February 2018. Two authors independently reviewed and selected articles based on predetermined criteria.

Results

A total of 30 studies with 56,458 NHL cases were finally selected, with 24, 9, and 3 studies on sunlight/ultraviolet radiation (UVR) exposure, dietary intake, and serum/plasma 25-hydroxyvitamin D levels, respectively. Significant protective effects of overall sunlight/UVR exposure on NHL and subtypes were observed, with summary relative risks (RRs) ranging from 0.67–0.80 (RR for NHL = 0.80 ; 95% confidence interval [CI]: 0.71–0.90) among subjects with high exposure compared to those with low exposure. The results were consistent with various classifications of sunlight/UVR exposure. In contrast, when exposure measures of dietary vitamin D intake (RR for NHL = 1.03; 95% CI: 0.90–1.19) and serum/plasma 25-hydroxyvitamin D levels (RR for NHL = 0.97; 95% CI: 0.82–1.15) were used, risk estimates were inconsistent or non-significant for NHL and the subtypes.

Conclusion

While risk estimates varied by different measures of vitamin D status, a protective effect of sunlight/UVR exposure on NHL incidence was verified, across most of the tested subtypes as well as exposure categories.

Non-Hodgkin's lymphoma occurs when your lymphocytes don't die

Normally, lymphocytes go through a predictable life cycle. Old lymphocytes die, and your body creates new ones to replace them.

In non-Hodgkin's lymphoma, your lymphocytes don't die, and your body keeps creating new ones. This oversupply of lymphocytes crowds into your lymph nodes, causing them to swell. Mayo Clinic