MRSA Carriers not helped by 4,000 IU of Vitamin D (probably poor Vitamin D Receptor) – RCT

Created July 2019

Vitamin D supplementation to persistent carriers of MRSA-a randomized and placebo-controlled clinical trial.

Eur J Clin Microbiol Infect Dis. 2018 Sep;37(9):1735-1744. doi: 10.1007/s10096-018-3306-7.

Björkhem-Bergman L1,2, Missailidis C3,4, Karlsson-Valik J5, Tammelin A5, Ekström L6, Bottai M7, Hammar U7, Lindh G8, Bergman P9,10.

Many studies have found MRSA to be associated with a poor Vitamin D Receptor Resveratrol is one of the ways to activate the Vitamin D receptor and thus get more Vitamin D to the tissues In this study the vitamin D level in the blood was raised to a good level of 40 ng, which is normaly enough to have a benefit however the tissues containing the MRSA apparently did not get much The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019 Blacks (who have lower levels of vitamin D) have 3.2 X higher MRSA risk Perplexity AI Dec 2024 British patients in National Health Service hospitals are 40 times more likely to get an MRSA infection than patients in other European countries. ~hs! Note: UK says 12 ng level of vitamin D is OK Vitamin D Receptor table shows what compensates for low VDR activation {include} Note: 2 ways to Improve activation of the Vitamin D Receptor: 1) Adding Reveratrol 2) Taking the vitamin D infrequently (~every two weeks) instead of daily --- 1. See MRSA, Vitamin D Receptor and Resveratrol * "Vitamin D's potential to reduce the risk of hospital-acquired infections" - 2012 - Vit D Receptor * "Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromsø Staph and Skin Study" 2012 10.1007/s10096-011-1331-x "RECEPTOR" occurs 7 times * [Search web for MRSA resveratrol](https://www.google.com/search?q=MRSA+resveratrol&oq;=MRSA+resveratrol&aqs;=chrome..69i57j0.7205j0j7&sourceid;=chrome&ie;=UTF-8%20) 96,000 as of July 2019 * [Search web for MRSA "vitamin d receptor"](https://www.google.com/search?q=mrsa+%22vitamin+d+receptor%22&oq;=mrsa+%22vitamin+d+receptor%22&aqs;=chrome..69i57.25345j0j7&sourceid;=chrome&ie;=UTF-8%20) 17,500 items as of July 2019 * "Resveratrol: A Double-Edged Sword in Health Benefits" Sept 2018 📄 Download the PDF from VitaminDWiki * Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019 VitaminDWiki * Rheumatoid Arthritis helped by Reseveratrol and/or infrequent Vitamin D - similar to MRSA * TB and Leprosy are easily confused and associated with Vitamin D Receptor like MRSA. they both have been treated by Antibiotics and things which increase the Vitamin D Receptor Unknown for MRSA Poor Receptor ==> MRSA OR MRSA ==> Poor Receptor Whereas for several Cancers Cancer ==> Poor Vitamin D Receptor that is, a Cancer has learned how to deactive the local VDR * Example: After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019

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Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to all beta-lactam antibiotics and can cause severe infections that are difficult to treat. Eradication strategies with conventional antibiotics are not always effective and alternative approaches are warranted. Here, we tested the hypothesis that daily supplementation with vitamin D for 12 months would reduce MRSA carriage rates among a group of persistent carriers. This was a double-blind, placebo-controlled randomized trial with n = 65 persistent MRSA carriers with 25-hydroxy vitamin D3 (25OHD) < 75 nmol/L, who were followed up with bacterial cultures at baseline and every 3 months for 1 year. The primary endpoint was the decline in MRSA positivity during the study period. The study was conducted in two MRSA outpatient clinics at the Karolinska University Hospital, Stockholm, Sweden. In total, n = 65 persistent MRSA carriers were randomized and n = 3 were lost to follow-up. Only patients deficient in vitamin D (< 75 nmol/L) were included. Vitamin D (4000 IU) or placebo/day was administered for 12 months. The decline in MRSA positivity was equal in the vitamin D and placebo group during the study period (OR, 1.00; 95% CI, 0.97-1.03; p = 0.928) and approximately 40% in both groups were MRSA-negative after 12 months. The vitamin D group produced 103 positive cultures out of 318 cultures (32.4%) from nose, throat, and perineum over the study period, whereas the placebo group produced 135/393 positive cultures (34.0%) (Fisher's exact test, p = 0.94). Vitamin D supplementation did not influence MRSA carriage. Thus, available data does not support vitamin D supplementation to persistent MRSA carriers.

Trial registration: www.clinicaltrials.gov ; NCT02178488.

People with healthy guts have far larger responses to 4,000 IU of vitamin D than those with MRSA

4,000 IU of Vitamin D daily is safe, but takes a year to plateau (Best-D) – RCT Dec 2016

Response by people with MRSA

Suspect that people with MRSA have poorer guts than health people

Tags: Immunity Vit D Receptor