Metabolites of pregnant blacks vary with vitamin D level

Created November 2014

Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents.

Reprod Sci. 2014 Nov 2. pii: 1933719114556477. [Epub ahead of print]

Finkelstein JL1, Pressman EK2, Cooper EM2, Kent TR1, Bar HY3, O'Brien KO4.

Study looked at 326 compounds For vitamin D > 20 ng (an OK, not a great level) * Higher: pyridoxate, bilirubin, xylose, and cholate * Lower: leukotrienes, 1,2-propanediol, azelate, undecanedioate, sebacate, inflammation associated complement component 3 peptide (HWESASXX), and piperine publisher wants $36 for the PDF 1. See also VitaminDWiki * Dark skin pregnancies and Vitamin D - many studies * Overview Pregnancy and vitamin D has the following summary {include}

Vitamin D is linked to a number of adverse pregnancy outcomes through largely unknown mechanisms. This study was conducted to examine the role of vitamin D status in metabolomic profiles in a group of 30 pregnant, African American adolescents (17.1 ± 1.1 years) at midgestation (26.8 ± 2.8 weeks), in 15 adolescents with 25-hydroxy vitamin D (25(OH)D) ≥20 ng/mL, and in 15 teens with 25(OH)D <20 ng/mL. Serum metabolomic profiles were examined using gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry. A novel hierarchical mixture model was used to evaluate differences in metabolite profiles between low and high groups. A total of 326 compounds were identified and included in subsequent statistical analyses. Eleven metabolites had significantly different means between the 2 vitamin D groups, after correcting for multiple hypothesis testing: pyridoxate, bilirubin, xylose, and cholate were higher, and leukotrienes, 1,2-propanediol, azelate, undecanedioate, sebacate, inflammation associated complement component 3 peptide (HWESASXX), and piperine were lower in serum from adolescents with 25(OH)D ≥20 ng/mL. Lower maternal vitamin D status at midgestation impacted serum metabolic profiles in pregnant adolescents.

© The Author(s) 2014.

PMID: 2536705

Tags: Darker Skin Pregnancy