Half as much chronic kidney disease infection if supplement with Vitamin D – 2018
Use of vitamin D and infection in patients with chronic kidney disease.
Rev Bras Enferm. 2018;71(suppl 6):2792-2799. doi: 10.1590/0034-7167-2018-0640.
[Article in English, Portuguese]
Silva ECD1, Taminato M1, Fonseca CDD1, Moraes GM1, Longo MCB1, Grothe CE1, Belasco AGS1, Barbosa DA1. ~ha~ dulce.barbosa@unifesp.br
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| Supplement | Infection |
| Vitamin D | 16 % |
| No D | 32 % |
| Blood level | Loading Dose | Maint. Dose |
| <20 ng/mL | 3 months | 3 months? |
| 20–19 ng/mL | 3 month; | 3 months? |
| >30 ng/mL | no | maintenance dose 3 month or 6 month? |
OBJECTIVE:
To evaluate the effectiveness of vitamin D supplementation as protection factor against infection of patients with chronic kidney disease on conservative treatment.
METHOD:
Retrospective cohort study carried out between 2013 and 2016 in the Conservative Treatment Outpatient Clinics (Ambulatório de Tratamento Conservador) of the Hypertension and Kidney Hospital (Hospital do Rim e Hipertensão) of the Universidade Federal de São Paulo. Data on sociodemographic factors, comorbidity, infection episodes and use or nonuse of vitamin D supplementation for at least 6 months were collected from medical records. The primary outcomes considered in both groups were: presence or absence of infection anywhere on the body (bloodstream, urinary, respiratory and surgical sites).
RESULTS:
A total of 263 patients were included and those who received (n=43) vitamin D had 59% less chance of developing infections (OR=0.41; 95%CI; 0.15-0.99), when compared to those who did not receive.
CONCLUSION: Vitamin D supplementation was a protective factor against infections of all causes.