CPR with low vitamin D – 10X more likely to have poor outcome within 3 months

Association Between Vitamin D Deficiency and Neurologic Outcomes in Patients After Cardiopulmonary Resuscitation

Shock. 2022 Jan 25. doi: 10.1097/SHK.0000000000001909

Bora Chae 1, Yo Sep Shin, Sang Min Kim, Seok-In Hong, Youn-Jung Kim, Seung Mok Ryoo, Won Young Kim

Aim: We investigated the association between vitamin D deficiency and neurologic outcomes after cardiopulmonary resuscitation.

Method: Data from the prospective cardiac arrest registry in the emergency department between October 2019 and April 2021 were retrospectively analyzed. Blood samples were obtained during cardiopulmonary resuscitation wherein 25-hydroxyvitamin D serum levels were analyzed; deficiency was defined as levels <10 ng/mL. The primary outcome was neurologic outcomes at 3 months assessed using the modified Rankin Scale.

Result: A total of 195 patients (mean age, 64.5 ± 16.1 years; 135 [69.2%] men) were included. A significantly greater proportion of patients with poor outcomes had vitamin D deficiency compared with those with good outcomes (49.4% vs. 18.2%, P = 0.001). The area under the curve for a sustained return of spontaneous circulation and 3-month poor neurologic outcomes was 0.595 (P = 0.031) and 0.704 (P < 0.001), respectively.

In a multivariate analysis,

• vitamin D deficiency (odds ratio (OR): 10.22; 95% confidence interval (CI): 1.47-70.82, P = 0.019),

• initial shockable rhythm (OR: 0.03; 95% CI: 0.00-0.84, P = 0.040),

• low flow time (OR: 1.10; 95% CI: 1.03-1.16, P = 0.003), and

• thrombocytopenia (OR: 10.66; 95% CI: 1.13-100.41, P = 0.039)

were significantly associated with 3-month poor neurologic outcomes.

Conclusion: The prevalence of vitamin D deficiency in patients with cardiac arrest was 44% and was associated with poor neurological outcomes at 3 months.

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VitaminDWiki - Probably much better outcome if restore Vitamin D ASAP after CPR

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VitaminDWiki - Restore Vitamin D before might reduce the risk of needing CPR

• Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019

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VitaminDWiki - relevant studies

• Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021

• Sudden cardiac arrest 6X worse outcome if low vitamin D – Nov 2014

• Heart attack ICU costs cut in half by Vitamin D – Oct 2018

• Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019

• Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012

• Recurrrent Cardiovascular deaths cut in half if 10 ng more Vitamin D – meta-analysis Sept 2021

• Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021