COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis

Created March 2021

Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies

The Journal of Steroid Biochemistry and Molecular Biology, https://doi.org/10.1016/j.jsbmb.2021.105883

Fausto Petrellia faupe@libero.IT, Andrea Luciania Gianluca Peregob Giuseppina Dogninic Paolo Luigi Colombellic Antonio Ghidinid

This study assumed that vitamin D for bone health should be applied to COVID-19 ( **< 20ng) The human body needs different levels of vitamin D to fight different health problems For example, need 50 ng to fight Infections Human bodies appear to need at least 40 ng** to fight COVID-19 The study mentions that vitamin D supplementation     (for any dose size, any duration), reduced risk of severe COVID-19 by 3.7 X --- 1. This study was the 10th Vitamin D and COVID-19 meta-analysis in VitaminDWiki {category} 1. COVID-19 treated by Vitamin D - studies, reports, videos {include}

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Highlights

  • Vitamin D modulates the systemic inflammatory response through interaction with immune system.

  • We systematically reviewed studies about vitamin D3 and risk and mortality for COVID-19 infection

  • Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection.

Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95% confidence interval (OR 95% CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients.

We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95% CI, 1.19-1.34; P < .01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients ( OR = 2.6 ; 95% CI, 1.84-3.67; P <  .01 and OR = 1.22; 95% CI, 1.04-1.43; P <  .01, respectively).

Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure.

Tags: Deficiency Meta-analysis Virus