Coronary Artery Disease 2.9 X more likely in postmenopausal women if Vitamin D deficient

Created March 2020

Association of Vitamin D Status With Coronary Artery Disease in Postmenopausal Women

Medicine (Baltimore) , 99 (11), e19544 Mar 2020, DOI: 10.1097/MD.0000000000019544

Rui Xu 1, Yan-Yan Li 2, Ling-Ling Ma 1, Hong-Ni Yang 1

Cardiovascular category starts with the following {include} --- Items in both categories Cardiovasular and women are listed here: {category} --- * Cardiovascular disease associated with postmenopausal non-human primates – meta-analysis Jan 2015

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The relationship between coronary artery disease (CAD) and low serum 25-hydroxyvitamin D (25(OH)D) levels has emerged. Postmenopausal (PM) women are at increased risk of CAD and vitamin D (VitD) deficiency. To investigate the relationship between CAD and VitD levels in PM women.This case-control study included 93 consecutive female patients aged 50 to 79 years old undergoing coronary angiography for evaluation of CAD and 119 age-matched controls. Serum 25(OH)D concentrations were classed as adequate (serum 25(OH)D: ≥20 ng/mL); insufficient (serum 25(OH)D: 10 to <20 ng/mL); and deficient (serum 25(OH)D: <10 ng/mL).

Major cardiovascular risk factors were also explored.CAD occurred in

  • 67/127 (52.8%) patients with VitD deficiency;

  • 21/66 (31.8%) patients that were VitD insufficient; and in

  • 5/19 (26.3%) patients with adequate VitD levels.

Multivariate regression analysis suggested that a deficiency of VitD increased CAD (odds ratio = 2.891 ; 95% confidence interval = 1.459-7.139, P < .001).

VitD deficiency should be evaluated in PM women as a possible cause of CAD.

GrassrootsHealth description of the study

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Tags: Cardiovascular Seniors Women