Clinically Isolated Syndrome progresses to Multiple Sclerosis, unless UVB treatments – RCT

Ultraviolet light offers MS relief

• “The trial, funded by MSWA, was carried out in 20 people with a clinically isolated syndrome — the first signs of a disease that could be MS but had yet to progress. All had sufficient levels of vitamin D.”

• “In the half of people given narrowband UVB treatment three times a week for eight weeks, only 30 per cent progressed to MS.”     vs 100% progressed without UVB

MS has been seen to benefit from UV more than Vitamin D in many previous studies VitaminDWiki suspects that something in addition to Vitamin D is made by UVB Unaware of UVB being "better" than vitamin D for any other health problems * Multiple Sclerosis suppressed by an Ultraviolet wavelength not associated with Vitamin D (mice) – Nov 2016 * Large variability in response to UV (more than response to oral Vitamin D) – March 2016 * All items in category UV and vitamin D ** items* * Items in both categories UV and Multiple Sclerosis are listed here: {category} --- 1. See also Web * Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis Lancet, May 2005 * ". . .only 30–70% of patients with a CIS develop MS" - vs 100% in the study on this page * Low Vitamin D Predicts MS in Clinically Isolated Syndromes July 2012 Medscape * "The patients in the lowest quartile of vitamin D levels experienced the highest rate of conversion to CDMS; the rate decreased through the third quartile, but for unexplained reasons, the rate of conversion among patients with the highest vitamin D levels was not much different from that of patients with the lowest level (see table below)"

Previously published description of the trial

Narrowband UVB Phototherapy for Clinically Isolated Syndrome: A Trial to Deliver the Benefits of Vitamin D and Other UVB-Induced Molecules.

Front Immunol. 2017 Jan 24;8:3. doi: 10.3389/fimmu.2017.00003. eCollection 2017.

Hart PH 1 prue.hart@telethonkids.org.au, Lucas RM2, Booth DR3, Carroll WM4, Nolan D5, Cole JM6, Jones AP1, Kermode AG7.

Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for MS development of higher 25(OH)D comes from observational studies, but this study design cannot separate out whether 25(OH)D is acting as a marker of vitamin D status, sun exposure, or both. In light of a lack of definitive outcomes in MS patients after trials of vitamin D supplementation and the ability of narrowband UVB to induce vitamin D, as well as other immune-regulatory molecules in skin, the Phototherapy for Clinically Isolated Syndrome (PhoCIS) trial was established to investigate the benefits of narrowband UVB, in addition to supplemented vitamin D, on MS development in individuals with Clinically Isolated Syndrome. We propose that the PhoCIS trial provides a fresh approach to re-defining the reported associations of 25(OH)D levels with MS development and progression.

PMID: 28167940   📄 Download the PDF from VitaminDWiki