Bone fractures reduced by a minimum of 800 IU vitamin D and Calcium – meta-meta-analysis
Vitamin D supplements with or without calcium to prevent fractures
BoneKEy Reports (2014) 3, Article number: 512 (2014) doi:10.1038/bonekey.2014.7
Received 02 September 2013 Accepted 05 November 2013 Published online 05 March 2014
Paul Lips, Evelien Gielen & Natasja M van Schoor
Vitamin D deficiency is associated with fractures. This relationship is biologically plausible. The results of 19 randomized clinical trials with vitamin D with or without calcium show varying results: a decreased fracture incidence in 7, neutral in 10 trials, whereas 2 trials with a high dose of vitamin D once per year showed an increased fracture incidence. In three out of four well-powered trials that used recommended doses of vitamin D 700–1000 IU per day, vitamin D supplementation did not significantly influence fracture risk. In one of these trials, a statistically significant fracture reduction was observed in nursing home residents having severe vitamin D deficiency, low calcium intake and good compliance.
Thirteen meta-analyses were done, and 11 of these showed a significantly decreased fracture incidence in the supplemented groups. Vitamin D alone was not effective, studies combining vitamin D and calcium showed inconsistent results. Analyses for vertebral fractures were negative in all cases. In conclusion, a vitamin D supplement of 800 IU per day in combination with calcium may decrease the incidence of non-vertebral fractures, especially in persons in the older age groups having low-baseline vitamin D status and low calcium intake and showing good compliance.
Table 2
PDF is attached at the bottom of this page
Comment by VitaminDWiki
Yes, need extra Calcium with low amount of vitamin D, but Calcium should be minimized with high level of vitamin D
Note: Following chart which shows that supplement suppliers reduce the Calcium as they increase the Vitamin D in pills
See also VitaminDWiki
IoM again fails to look at interactions - Nov 2010 has the following chart
Meta-analysis of Falls and Fracture in VitaminDWiki
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