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Bone Mineral Density and Vitamin D - many studies


55+ VitaminDWiki pages with BONE MINERAL DENSITY or BONE LOSS in the title

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Meta-analysis of Vitamin D and Bone Mineral Density - April 2023

Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis
Nutr Rev . 2023 Apr 11;81(5):511-530. doi: 10.1093/nutrit/nuac068 behind publisher paywall
Elham Kazemian 1, Ali Pourali 2, Fatemeh Sedaghat 3, Mehrdad Karimi 4, Vahid Basirat 5, Zohreh Sajadi Hezaveh 6 7, Sayed Hossein Davoodi 7, Michael F Holick 8

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Context: There is still controversy over the effect of vitamin D3 supplementation on bone health.

Objective: The effects of vitamin D3 supplementation on bone mineral density (BMD) and markers of bone turnover, as well as the dose-response relationship between vitamin D3 and bone health in adults, were evaluated.

Data sources: The PubMed, Scopus, Cochrane, Web of Science, and AGRIS databases were searched for articles published through April 30, 2022. Thirty-nine of the 6409 records identified met the inclusion criteria.

Data extraction: Data were extracted from articles by 2 authors, and data extraction was cross-checked independently. A random-effects model was used to estimate the pooled effect size and the associated 95%CI for the effect of vitamin D3 for each outcome. A one-stage random-effects dose-response model was used to estimate the dose-response relationship between vitamin D3 supplementation and BMD.

Data analysis: Results of meta-analysis showed a beneficial effect of vitamin D3 at the

  • lumbar spine (standardized mean difference [SMD] = 0.06; 95%CI, 0.01-0.12) and
  • femoral neck (SMD = 0.25; 95%CI, 0.09-0.41).

Dose-response analysis revealed a linear relationship between vitamin D3 supplementation doses and

  • BMD at the femoral neck,
  • lumbar spine, and
  • total hip sites.

No significant effect of vitamin D3 supplementation on whole-body or total hip BMD was observed (P > 0.05). Vitamin D3 supplementation significantly decreased BMD at both proximal and distal forearm (SMD = -0.16; 95%CI, -0.26 to -0.06). The variables of ethnicity, age, baseline 25-hydroxyvitamin D (25[OH]D), menopause status, vitamin D3 dosing frequency, and bone health status (P interaction = 0.02) altered the effect of vitamin D3 supplementation on BMD. Additionally, a nonlinear relationship between vitamin D3 supplement doses and markers of bone turnover was found.

Conclusion: A protective effect of vitamin D3 supplementation on BMD of the lumbar spine, femoral neck, and total hip is implicated.


VitaminDWiki – Bone - Health category contains

307 items in Bone - Health category
See also

VitaminDWiki – Overview Osteoporosis and vitamin D contains

  • FACT: Bones need Calcium (this has been known for a very long time)
  • FACT: Vitamin D improves Calcium bioavailability (3X ?)
  • FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
  • FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
  • FACT: Vitamin D supplements are very low cost
  • FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
  • FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
  • FACT: Co-factors help build bones.
  • FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
  • It appears that to TREAT Osteoporosis:
  •        Calcium OR vitamin D is ok
  •        Calcium + vitamin D is good
  •        Calcium + vitamin D + other co-factors is great
  •        Low-cost Vitamin D Receptor activators sometimes may be helpful
  • CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
  • Category Osteoporosis has 215 items
  • Category Bone Health has 307 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones


VitaminDWiki - 32 studies in both categories Bone AND Osteoporosis

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Attached files

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19778 BMD vit D.jpg admin 09 Jul, 2023 18.80 Kb 384