Excess Uric Acid associated with low vitamin D

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Gout and Vitamin D in VitaminDWiki

Gout and Vitamin D - many studies has the following summary and image

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Uric Acid and some Kidney stones

Overview Kidney Stones and vitamin D
Note: A fraction of Kidney stones are associated with Uric Acid (low vitamin D)

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Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis - Sept 2015

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Association Between Vitamin D and Hyperuricemia Among Adults in the United States- Nov 2020

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Uric acid and Vitamin D linked to PTH - July 2021

Vitamin D and Uric Acid: Is Parathyroid Hormone the Missing Link?
Journal of Clinical & Translational Endocrinology. Available online 8 July 2021, https://doi.org/10.1016/j.jcte.2021.100263
Letters to the editor

With interest, we read the article of Nimitphong et al. [1], which revealed the potential uric-lowering effect of vitamin D supplementation in patients with prediabetes and hyperuricemia. The result of this study supports the causal association between vitamin D deficiency and insufficiency and elevated serum uric acid that has been shown in previous observational studies 2 independent of the fact that the association might also be confounded by presence of comorbid obesity and metabolic syndrome.
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Some amount of Vitamin D reduces uric acid concentations - meta-analysis of clinical trials May 2024

Effect of vitamin D administration on serum uric acid concentrations: a systematic review and meta-analysis of clinical trials
PharmaNutrition online 17 May 2024,https://doi.org/10.1016/j.phanu.2024.100391 PDF behind paywall
Luis E. Simental-Mendía a, Yéssika Weyman-Vela a, Mario Simental-Mendía b 1

Background
It has been suggested the potential uric acid-lowering effect of vitamin D; however, clinical trials evaluating the impact of vitamin D administration on serum uric acid levels are scarce. The aim of this meta-analysis of clinical trials was to examine the effect of vitamin D administration on serum uric acid concentrations.

Methods
A systematic search was performed in PubMed-MEDLINE, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases. Randomized clinical trials (parallel or cross-over design) with data at baseline and at the end of intervention. Trials without intervention, without control group, and incomplete data of uric acid concentrations were excluded. A random-effects model and sensitivity analysis generic inverse variance method were used for the meta-analysis.

Results
Meta-analysis was carried out using a random-effects model and sensitivity analysis. The meta-analysis of seven clinical trials, involving 959 participants, indicated a significant reduction of uric acid levels after vitamin D administration (WMD: -16.64 µmol/L, 95% CI: -25.25, -8.03, p <0.001, I2 = 74%). Additionally, the impact of this vitamin on uric acid concentrations was robust in the leave-one-out sensitivity analysis.

Discussion
Given that few clinical trials were included, the number of subjects analyzed was limited. However, our results suggest that vitamin D administration is associated with a significant reduction in the levels of serum uric acid in randomized clinical trials.

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Association Between Vitamin D and Uric Acid in Adults:A Systematic Review and Meta-Analysis - Sept 2020

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Low D, high Uric - meta-analysis March 2019

Vitamin D insufficiency and deficiency are associated with a higher level of serum uric acid: A systematic review and meta-analysis
Mod Rheumatol. 2019 Mar 4:1-6. doi: 10.1080/14397595.2019.1575000
Charoenngam N1, Ponvilawan B2, Ungprasert P3.
1 Department of Medicine, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.
2 Department of Pharmacology, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.
3 Department of Research and Development, Faculty of Medicine Siriraj Hospital, Clinical Epidemiology Unit , Mahidol University , Bangkok , Thailand.
INTRODUCTION/OBJECTIVES:
Several epidemiological studies have suggested that patients with vitamin D insufficiency and deficiency tend to have a higher level of serum uric acid compared with those with adequate vitamin D level although the results were inconsistent across the studies. The current systematic review and meta-analysis was conducted with the aim to summarize all the available data.

METHODS:
A systematic review was conducted using MEDLINE and EMBASE database from inception to May 2018 to identify all studies that compared the level of serum uric acid between individuals with normal vitamin D level and patients with vitamin D insufficiency/deficiency. Eligible studies must be cohort or cross-sectional studies that consisted of two groups of adult participants, one with normal level of vitamin D (vitamin D level >30 ng/ml) and one with vitamin D insufficiency (vitamin D level 20-30 ng/ml) or vitamin D deficiency (vitamin D level of <20 ng/ml). Mean serum uric acid level and standard deviation of participants were extracted from each study to calculate mean difference (MD). Pooled MD was then calculated by combining MDs of each study using random-effects model.

RESULTS:
A total of seven cross-sectional studies were eligible for the meta-analyses. Individuals with normal vitamin D level had a significantly lower serum uric acid level than patients with vitamin D insufficiency with the pooled MD of -0.33 mg/dl (95%CI, -0.61, -0.04), and also had a significantly lower serum uric acid level than patients with vitamin D deficiency with the pooled MD of -0.45 mg/dl (95%CI, -0.82, -0.08). The statistical heterogeneity of these meta-analyses was high with the I2 of 78% and 89%, respectively. Funnel plots of both meta-analyses were fairly symmetric and did not provide a suggestive evidence for the presence of publication bias.

CONCLUSION: Both patients with vitamin D insufficiency and patients with vitamin D deficiency had a significantly higher level of serum uric acid compared with individuals with normal vitamin D level.
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