Vitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors

Created July 2018

Postural Balance and Vitamin D Receptor Gene Polymorphism in Physically Independent Older Adults

International Conference on Applied Human Factors and Ergonomics. AHFE 2018:

Advances in Human Factors and Ergonomics in Healthcare and Medical Devices pp 397-404 |

https://doi.org/10.1007/978-3-319-94373-2_44

Regina Poli-Frederico Marcos Fernandes Rubens A. da Silva Karen Fernandes

G1 (44% ) = TT genotype group = poorer balance G2 (56%) = TC or CC genotypes = better balance Balance Test image Need more balance area (Center of Pressure) for 1-legged stand: 14 vs 10 image Sway more if TT VDR image --- Note: Falls are associated with low Vitamin D blood levels The VDR (TT) restricts how of it actually gets to the cells * Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017 * Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015 * Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016 Falls and Fractures category contains the following summary {include} Vitamin D Receptor category has the following {include}

PDF is available free at Sci-Hub    10.1007/978-3-319-94373-2_44

This study aimed to assess the association between VDR polymorphisms and postural balance in physically independent elderly. 142 elderly persons were enrolled at this case-control study. In order to assess the balance, the individuals performed three 30-s trials of one-legged stance balance test on a BIOMEC400 force-platform (EMG System of Brazil, SP Ltda.), following a standardized protocol (with 30 s of rest between each trial). The main balance parameters used for analysis were: center of pressure area (COP), sway velocity (cm/s) and frequency (s) in both the antero-posterior (A/P) and the medio-lateral (M/L) axes. The VDR TaqI polymorphism analysis was by PCR-RFLP. The case group showed lower values of COP, sway velocity in A/P and M/L axes (p = 0.0007). Similar data were observed regarding frequency in A/P (p = 0.04) and M/L axes (p = 0.03). Therefore, carriers of the “C” allele have a better postural balance when compared to individuals with “T” allele.

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Tags: Falls and Fractures Vit D Receptor