Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis

Created November 2012

Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

Genetic Testing and Molecular Biomarkers – Nov 2012

Rui-Fen Sun,2,* Qun-Hui Li,1 Da-Xing Wang,1 Feng Zhao,1 Jun-Min Li,1 Qi Pu,1 Zhong-Zi Zhang,1 Yan Jin,1 Bai-Lian Liu,1 and Ying Xiong1

1 Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.

2 Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, People's Republic of China.

Address correspondence to: Bai-Lian Liu, M.D.; Department of Orthopedics, Kunming Medical University. National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051

People's Republic of China, E-mail: 1628322036@qq.com

Ying Xiong, M.D.; Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051, People's Republic of China. E-mail: xiongying789@126.com

Objective: Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.

Methods: Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (Cis).

Results: The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (

  • bb vs. BB: OR= 0.61 , 95% CI, 0.40–0.92;

  • bb vs. BB/Bb: OR= 0.70 , 95% CI, 0.52–0.95, respectively).

Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in

  • postmenopausal women (bb vs. BB/Bb: OR= 0.68 , 95% CI, 0.46–0.98) and

  • Africans (Bb/bb vs. BB: OR= 0.18 , 95% CI, 0.09–0.37).

Conclusion: The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.

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PDFs of paper and supplemental data are at bottom of this web page

Forest plot of the meta-analysis (bb vs. BB)

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Blacks are particularly affected (supp table 2)

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See also VitaminDWiki

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