Vitamin D levels needed to protect against various diseases - meta-analysis

The Optimal Protective 25-Hydroxyvitamin D Level for Different Health Outcomes in Adults: A Brief Summary of Dose–Response Meta-Analyses

Metabolites 2025, 15(4), 264; https://doi.org/10.3390/metabo15040264

by Cem Ekmekcioglu * and Michael PoteserORCID

Department of Environmental Health, Center for Public Health, Medical University of Vienna, 1090 Vienna, Austria

Vitamin D is very important for bone metabolism as well as for the prevention of various diseases, such as type 2 diabetes, cardiovascular disease and different types of cancer. Although vitamin D deficiency is widespread and an important public health problem, there exists controversy in the scientific community, with no established standard definition of adequate and deficient vitamin D status. To add new information on this topic, the aim of this brief opinion paper is to identify and discuss the optimal 25(OH)D concentration (range) for a reduction in the risk of various disease outcomes by summarizing dose–response reporting meta-analyses.

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