Vitamin D fights treatment-resistant cancers (petrie dish)

Created June 2019
Vitamin D may be able to treat many multidrug-resistant diseases Cells which pump drugs out of them have the protein MRP1 Calcitriol kills cells with MRP1 (in Petrie dish) This may be the reason that Vitamin D helps Chemo, etc.

How vitamin D helps fight treatment-resistant cancer Medical News Today

  • “The researchers showed that calcitriol and calcipotriol can selectively hone in on cancer cells that have too much MRP1 and destroy them”

  • “… multidrug resistance-associated protein 1 (MRP1). The protein sits in the cell wall and drives a pump that ejects cancer drugs out of the cell.”

  • “Cancer cells that develop resistance to chemotherapy drugs often overexpress, or overproduce, transporter proteins. This abundance is the primary cause of chemoresistance”

  • “ MRP1 doesn't just reduce the effectiveness of cancer drugs, it can also weaken the effect of antibiotics, antivirals, anti-inflammatories, antidepressants, and drugs that treat HIV. ”

Reference

Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells

Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews and Surtaj H. Iram

Drug Metabolism and Disposition December 2018, 46 (12) 1856-1866; DOI: https://doi.org/10.1124/dmd.118.081612

📄 Download the PDF from VitaminDWiki

MRP1 connection may explain many of the following * Chemotheraphy not work as well with low Vitamin D (colon cancer this time) – Aug 2018 * Chemotherapy drugs often reduce Vitamin D levels, restoring levels helps– Aug 2018 * Breast cancer recurred twice as often if have less than 20 ng of vitamin D – Dec 2018 * Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017 * Recurrence of head and neck cancer reduced by half in those getting more vitamin D (in food) – May 2018 * Cancer treatment helped by Vitamin D, C, and E – Book 2017 * Chemotherapy might be augmented with Vitamin D – Jan 2017 Calcitriol in VitaminDWiki * * Calcitriol category listing has items along with related searches** * Active vitamin D appears to treat cancer – more studies needed – June 2018 Quick Chemo look on the web | | | | --- | --- | | Known | Half of late-stage cancer patients get chemotherapy | | Unknown | % of Cancers which are now Chemo resistant |
Tags: Cancer - after diagnosis