Vitamin D deficiency increases risk of Dementia by 1.4 X and Alzheimer’s by 1.5 X – Meta-analysis
Association of Vitamin D Levels with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Studies
Journal: Journal of Alzheimer's Disease, March 2024 DOI: 10.3233/JAD-231381
Zhang, Xiao-Xuea; b | Wang, He-Ranb | Hu, Ya-Zhuob | Sun, Hong-Meia; b | Feng, Yu-Xina; b | Jia, Jian-Juna; b; *
Background: Emerging evidence suggests the potential relationship between vitamin D deficiency and risk of cognitive impairment or dementia. To what extent the excess risk of dementia conferred by vitamin D deficiency is less clear. Objective: We summarized the current evidence from several aspects and further quantified these associations.
Methods: We collected relevant prospective cohort studies by searching PubMed, Embase and Cochrane up to July 2023. The pooled relative risks (RR) were evaluated by random-effects models. Dose-response analyses were conducted by the method of two-stage generalized least squares regression.
Results: Of 9,267 identified literatures, 23 were eligible for inclusion in the meta-analyses, among which 9 and 4 literatures were included in the dose-response analyses for the risk of dementia and Alzheimer’s disease (AD).
Vitamin D deficiency exhibited a 1.42 times risk for dementia (95% confidence interval (CI) = 1.21–1.65) and a
1.57-fold excess risk for AD (95% CI = 1.15–2.14).
And vitamin D deficiency was associated with 34% elevated risk with cognitive impairment (95% CI = 1.19–1.52). Additionally, vitamin D was non-linearly related to the risk of dementia (p nonlinearity = 0.0000) and AD (p nonlinearity = 0.0042). The approximate 77.5–100 nmol/L 25-hydroxyvitamin D [25(OH)D] was optimal for reducing dementia risk. And the AD risk seemed to be decreased when the 25(OH)D level >40.1 nmol/L.
Conclusions: Vitamin D deficiency was a risk factor for dementia, AD, and cognitive impairment. The nonlinear relationships may further provide the optimum dose of 25(OH)D for dementia prevention.
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VitaminDWiki – Overview Alzheimer's-Cognition and Vitamin D contains:
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VitaminDWiki – Dementia is associated with low vitamin D - many studies
Which as of March 2024 contained
Vitamin D reduced Dementia in VA by 40% - Dr. Campbell March 2023
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VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D
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Vitamin D deficiency as a risk factor for dementia: a systematic review and meta-analysis - 2017
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VITAMIN D AND DEMENTIA - 2016
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Grassrootshealth report and chart on the study March 2024
