25-hydroxyvitamin d and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 british birth cohort.

PLoS One. 2010 May 24;5(5):e10801.

Hyppönen E, Berry D, Cortina-Borja M, Power C.

Medical Research Council Centre for Epidemiology of Child Health and Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, United Kingdom.

BACKGROUND: Vitamin D deficiency has been suggested as a cardiovascular risk factor , but little is known about underlying mechanisms or associations with inflammatory or hemostatic markers. Our aim was to investigate the association between 25-hydroxyvitamin D [25(OH)D, a measure for vitamin D status] concentrations with pre-clinical variations in markers of inflammation and hemostasis.

METHODOLOGY/PRINCIPAL FINDINGS: Serum concentrations of 25(OH)D, C-reactive protein (CRP), fibrinogen, D-dimer, tissue plasminogen activator (tPA) antigen, and von Willebrand factor (vWF) were measured in a large population based study of British whites (aged 45y). Participants for the current investigation were restricted to individuals free of drug treated cardiovascular disease (n = 6538). Adjusted for sex and month, 25(OH)D was inversely associated with all outcomes (p/=75 nmol/l compared to <25 nmol/l. D-dimer concentrations were lower for participants with 25(OH)D 50-90nmol/l compared to others (quadratic term p = 0.01). We also examined seasonal variation in hemostatic and inflammatory markers, and evaluated 25(OH)D contribution to the observed patterns using mediation models. TPA concentrations varied by season (p = 0.02), and much of this pattern was related to fluctuations in 25(OH)D concentrations (p items