Total Testosterone increased if take more than 4,000 IU vitamin D daily – meta-analysis
The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review
Diseases 2024, 12(10), 228; https://doi.org/10.3390/diseases12100228
by Ahmed Abu-Zaid 1,*,Saleh A. K. Saleh 2ORCID,Heba M. Adly 3ORCID,Saeed Baradwan 4ORCID,Abdullah M. Alharran 5ORCID,Mshal Alhatm 6,Mooza M. Alzayed 5,Muteb N. Alotaibi 6,Abdulbadih Rabih Saad 5,Hessa Mohammed Alfayadh 7,Mohammed Abuzaid 8 and Osama Alomar 9
Background: Recent studies indicate that vitamin D impacts male reproductive function, with deficiency linked to infertility. This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testosterone, the free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex-hormone-binding globulin (SHBG), and estradiol.
Methods: We systematically searched Medline, Web of Science, Cochrane Library, and Scopus from their inception until July 2024 for randomized controlled trials (RCTs) involving adult males. The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Evidence quality was assessed using ROB2 and GRADE. Meta-regression and dose–response analyses were performed.
Results: Seventeen studies met the criteria for quantitative analysis.
Vitamin D supplementation significantly increased total testosterone levels (WMD 0.38, 95% CI 0.06–0.70, n = 15, I2 = 67.03).
However, it had no significant effect on other hormone parameters: free testosterone (WMD 0.00, 95% CI −0.02–0.03, n = 9, I2 = 48.12), FSH (WMD −0.02, 95% CI −0.57–0.53, n = 7, I2 = 48.72), LH (WMD −0.09, 95% CI −0.30–0.12, n = 8, I2 = 0.00), SHBG (WMD 0.73, 95% CI −1.14–2.61, n = 10, I2 = 69.05), FAI (WMD −0.92, 95% CI −2.12–0.27, n = 6, I2 = 0.00), and estradiol (WMD −0.02, 95% CI −2.95–2.92, n = 5, I2 = 20.63).
Conclusion: This meta-analysis shows that vitamin D supplementation may increase total testosterone levels in men. However, further well-designed RCTs are needed to determine vitamin D’s effects on other reproductive hormone parameters.
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VitaminDWiki – Vitamin D greatly improves Fertility
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