Taking vitamin D for health problems has raised D levels a bit (child Arthritis this case)

Created July 2021

Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

Nutr Res. 2021 Jun 13;92:139-149. doi: 10.1016/j.nutres.2021.05.007

Sarah L Finch 1, Alan M Rosenberg 2, Anthony J Kusalik 3, Farhad Maleki 3, Elham Rezaei 3, Adam Baxter-Jones 3, Susanne Benseler 4, Gilles Boire 5, David Cabral 6, Sarah Campillo 7, Gaëlle Chédeville 7, Anne-Laure Chetaille 8, Paul Dancey 9, Ciaran Duffy 10, Karen Watanabe Duffy 10, Jaime Guzman 6, Kristin Houghton 6, Adam M Huber 11, Roman Jurencak 10, Bianca Lang 11, Ron M Laxer 12, Kimberly Morishita 6, Kiem G Oen 13, Ross E Petty 6, Suzanne E Ramsey 11, Johannes Roth 10, Rayfel Schneider 12, Rosie Scuccimarri 7, Elizabeth Stringer 11, Shirley M L Tse 12, Lori B Tucker 6, Stuart E Turvey 6, Michael Szafron 3, Susan Whiting 3, Rae Sm Yeung 12, Hassan Vatanparast 14, BBOP Study Group

* 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020 * UK people with Multiple Sclerosis are 3X more likely to take Vitamin D - Oct 2020 * 26 X increase in Vitamin D prescriptions for youths in England in 8 years – Dec 2019 * The use of Vitamin D to prevent prostate cancer doubled in a decade – May 2019 * Vitamin D is perceived to be the healthiest food ingredient (more than fiber, whole grains, Omega-3, organic, etc) Survey May 2018 * Vitamin D is the most popular supplement, and was in the first commercial supplement – cod liver oil – May 2018 * Parkinson’s patients – 41 percent now supplement with Vitamin D – Nov 2017 * 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013 1. juvenile idiopathic arthritis in VitaminDWiki * Juvenile Idiopathic Arthritis is strongly associated with low vitamin D – many studies * Arthritic children have low vitamin D (84 percent of the studies) – May 2018 JIA * Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018 * In addition to taking Vitamin D, many would be aided by taking suppolements to activate their vitamin D receptors Items in both categories Rheumatoid Arthritis and infant-Child are listed here: {category} 1. Now doctors need to learn to prescribe enough vitamin D to make a difference * Less than 3 percent of hip fracture patients prescribed enough Vitamin D to make a difference (Malta in this case) – July 2021 * 21 reasons why doctors are reluctant to accept Vitamin D * Do not expect a doctor to recommend a pill which will eliminate his job (vitamin D) * Curing patients is not a sustainable business model – Goldman Sachs – April 2018 * VITAMIN D: Public Shouldn’t Wait For Doctors To Usher In New “Golden Era” Of Preventive Medicine * Let 1000 die from vitamin D deficiency rather than incur 1 lawsuit * Survey Shows Dogma Not Data Can Dictate Doctors' Decisions - June 2010

A number of studies have demonstrated that patients with autoimmune disease have lower levels of vitamin D prompting speculation that vitamin D might suppress inflammation and immune responses in children with juvenile idiopathic arthritis (JIA). The objective of this study was to compare vitamin D levels in children with JIA at disease onset with healthy children. We hypothesized that children and adolescents with JIA have lower vitamin D levels than healthy children and adolescents. Data from a Canadian cohort of children with new-onset JIA (n= 164, data collection 2007-2012) were compared to Canadian Health Measures Survey (CHMS) data (n=4027, data collection 2007-2011). We compared 25-hydroxy vitamin D (25(OH)D) concentrations with measures of inflammation, vitamin D supplement use, milk intake, and season of birth. Mean 25(OH)D level was significantly higher in patients with JIA (79 ± 3.1 nmol/L) than in healthy controls (68 ± 1.8 nmol/L P <.05). Patients with JIA more often used vitamin D containing supplements (50% vs. 7%; P <.05). The prevalence of 25(OH)D deficiency (<30 nmol/L) was 6% for both groups. Children with JIA with 25(OH)D deficiency or insufficiency (<50 nmol/L) had higher C-reactive protein levels. Children with JIA were more often born in the fall and winter compared to healthy children. In contrast to earlier studies, we found vitamin D levels in Canadian children with JIA were higher compared to healthy children and associated with more frequent use of vitamin D supplements. Among children with JIA, low vitamin D levels were associated with indicators of greater inflammation.

Tags: Increased use of D Infant-Child Rheumatoid Arthritis