Suicide attempts by males 3.7 X more likely if poor Vitamin D gene (CYP24A1)
Effects of vitamin D-related gene polymorphisms on attempted suicide
Psychiatric Genetics, Volume 31, Number 6, 22 October 2021, pp. 230-238(9)
https://doi.org/10.1097/YPG.0000000000000295 PDF is behind a $52 paywall
Wei, Yan-Xin; Liu, Bao-Peng; Qiu, Hui-Min; Zhang, Ji-Yu; Wang, Xin-Ting; Jia, Cun-Xian
Objective
Emerging evidence suggests that vitamin D might protect from attempted suicide. The study aimed to investigate the associations between single-nucleotide polymorphisms (SNPs) related to vitamin D levels identified in a large genome-wide association study and attempted suicide in rural China.
Methods
This 1:1 matched case–control study included altogether 510 suicide attempters and 510 community controls.
Genotypes of four target SNPs (
DHCR7-rs12785878,
CYP2R1-rs10741657,
GC-rs2282679, and
CYP24A1-rs6013897)
were determined, and a genetic risk score (GRS) was constructed to evaluate the combined effect of them. Demographic and psychological information was acquired through face-to-face interviews.
Results
The A allele of CYP24A1-rs6013897 was significantly associated with attempted suicide (OR = 1.27, 95% CI, 1.03–1.58, P = 0.029), even after adjusting for demographic and psychological confounders (adjusted OR = 1.53, 95% CI, 1.01–2.30, P = 0.043). The GRS analyses revealed a significantly higher risk of attempted suicide with a greater number of low vitamin D alleles (adjusted OR = 1.33, 95% CI, 1.13–1.58, P < 0.001).
Subgroup analyses stratified by sex indicated that the genetic associations were only significant among males with adjusted ORs of 3.77 (95% CI, 1.56–9.10) for the A allele of rs6013897 and 2.04 (95% CI, 1.32–3.17) for GRS.
Conclusions
Our findings identity CYP24A1-rs6013897 as a potential biomarker for attempted suicide and indicate that a genetic predisposition to lower vitamin D levels may contribute to attempted suicide. It suggests the possibility that vitamin D may have the preventive potential for attempted suicide.
VitaminDWiki - Suicide associated with low vitamin D - many studies
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Blood test does not notice when a poor CYP24A1 gene stops Vitamin D from getting to cells
