Poor Vitamin D Binding Protein Genes increase the risk of various diseases
rs7041 and rs4588 Polymorphisms in Vitamin D Binding Protein Gene (VDBP) and the Risk of Diseases
Int J Mol Sci. 2022 Jan 15;23(2):933. doi: 10.3390/ijms23020933.
Dominika Rozmus 1, Janusz Płomiński 2 3, Klaudia Augustyn 4, Anna Cieślińska 1
The purpose of the study was to investigate the role of vitamin D binding protein (VDBP, DBP) and its polymorphism in the vitamin D pathway and human health. This narrative review shows the latest literature on the most popular diseases that have previously been linked to VDBP. Vitamin D plays a crucial role in human metabolism, controlling phosphorus and calcium homeostasis. Vitamin D binding protein bonds vitamin D and its metabolites and transports them to target tissues. The most common polymorphisms in the VDBP gene are rs4588 and rs7041, which are located in exon 11 in domain III of the VDBP gene. rs4588 and rs7041 may be correlated with differences not only in vitamin D status in serum but also with vitamin D metabolites. This review supports the role of single nucleotide polymorphisms (SNPs) in the VDBP gene and presents the latest data showing correlations between VDBP variants with important human diseases such as
obesity,
diabetes mellitus,
tuberculosis,
chronic obstructive pulmonary disease,
and others.
Note: This chart only shows vitamin D from the skin, and none from the mouth
Note: This chart shows interaction BEFORE the Liver and after the kidneys%% VitaminDWiki charts show interaction AFTER the liver
In this review, we aim to systematize the knowledge regarding the occurrence of diseases and their relationship with vitamin D deficiencies, which may be caused by polymorphisms in the VDBP gene. Further research is required on the possible influence of SNPs, modifications in the structure of the binding protein, and their influence on the organism. It is also important to mention that most studies do not have a specific time of year to measure accurate vitamin D metabolite levels, which can be misleading in conclusions due to the seasonal nature of vitamin D.
📄 Download the PDF from VitaminDWiki
Sections of the PDF include
Bone Density.
Obesity
Polycystic Ovarian Syndrome (PCOS)
Metabolic Syndrome (MetS)
Postmenopausal WomenDiabetes Mellitus (DB)
Diabetes
Asthma
Pulmonary Tuberculosis (PTB, TB).
Chronic Obstructive Pulmonary Disease
Coronary Artery Disease
Multiple Sclerosis
Parkinson’s Disease
VitaminDWiki - Vitamin D Binding Protein category listing has items and the following introduction__
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VitaminDWiki - Vitamin D Binding Protein has a list of health problems
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VitaminDWiki - Vitamin D Gene chart - including VDBP
