Pfizer’s RSV vaccine found to increase risk of preterm births by 24%, etc.
Physician-Researchers Find Pfizer Maternal RSV Vaccination (Bivalent RSVpreF) Linked to 24% Increased Risk of Preterm Delivery
When reviewing the studies with a “safety first” perspective “many maternal side effects were greater in the RSVpreF group, with an increased incidence of
local reactions (RR, 5.98 [3.68, 6.83]; P=0.01; I2=0%),
joint pain (RR, 1.60, 1.39 [0.68, 2.86]; P=0.37; I2=59%),
cardiac disorders (RR, 1.19 [0.80, 1.77]; P=0.38; I2=0%),
blood disorders (RR, 1.07 [0.69, 1.66]; P=0.78; I2=0%),
fatigue (RR, 1.05 [1.00, 1.10]; P=0.07; I2=0%),
headache (RR, 0.80 [0.30, 2.10]; P=0.65; I2=0%),
fever (RR, 0.90 [0.20, 4.16]; P=0.89; I2=57%),
gastrointestinal disorders (RR, 1.04 [0.70, 1.56]; P=0.83; I2=0%), and
pregnancy complications (RR, 1.01 [0.65, 1.56]; P=0.97; I2=17%).”
References
RSVpreF vaccination in pregnancy: a meta-analysis of maternal-fetal safety and infant efficacy
Obstet Gynecol Sci. 2024 Sept FREE PDF
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