Periodontitis treated by 4,000 IU of Vitamin D (pilot study)

Created March 2019

The Influence of Vitamin D Supplementation on Local and Systemic Inflammatory Markers in Periodontitis Patients: A Pilot Study.

Oral Dis. 2019 Mar 26. doi: 10.1111/odi.13097

Meghil MM1,2, Hutchens L1, Raed A3, Multani NA4, Rajendran M1, Zhu H3, Looney S5, Elashiry M1,2, Arce RM1, Peacock ME1, Dong Y3, Cutler CW1.

* Periodontitis probably related to low Vitamin D – review June 2018 * Periodontitis associated with low Vitamin D if dark-skinned – Dec 2018 * Periodontitis probably related to low Vitamin D – review June 2018 * Chronic Periodontitis 9.6 times more likely if smoke and have poor Vitamin D Receptor – Aug 2016 * Chronic Periodontitis reduced by Omega-3 – RCT Sept 2018 * Periodontitis with low Vitamin D increases risk of Diabetes by 2.8 X – July 2018 * Vitamin D may provide the most periodontal benefits of all nutraceuticals – May 2018 * Generalized Aggressive Periodontitis is 3X more likely if too much Vitamin D-Binding Protein – Nov 2016 * Which reduces how much vitamin D actually gets to the cells * * Dental category listing has items along with related searches * Search VitaminDWiki for Periodontitis 439 items as of March 2019** --- 1. # Items in both categories Dental and Vitamin D Receptor are listed here: {category}

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OBJECTIVES:

Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation on mediators of systemic inflammation in dark-skinned, periodontitis patients.

MATERIALS AND METHODS:

A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or Placebo group and received intensive single visit scaling and root planing to elicit a systemic inflammatory response.

RESULTS:

Vitamin D supplementation (VDS) increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs.

CONCLUSION:

In conclusion, vitamin D supplementation has multiple benefits for reducing systemic inflammation and promoting induction of autophagy related proteins related to anti-microbial functions.

Tags: Dental Intervention