Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change

Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population.

J Ovarian Res. 2013 May 26;6(1):37.

Mohapatra S, Saxena A, Gandhi G, Koner BC, Ray PC.

INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined.

OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer.

MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay.

RESULTS: Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37 , 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype.

Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value < 0.4).

CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.

PMID: 23705897

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Second study one month later (June 2013) is also attached at the bottom of this page

Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis PLOS ONE

16% increase

See also VitaminDWiki

• Ovarian Cancer: Interplay of Vitamin D Signaling and miRNA Action. – 2014

• Ovarian cancer: more likely to survive if more vitamin D – Aug 2012

• Calcium and vitamin D appear to be among the few ways to prevent ovarian cancer – 2010

• Ovarian Cancer is somewhat associated with a reduction in 20 ng of vitamin D – Feb 2011

• Difference in Fok gene reduced response to vitamin D by 35 percent – Nov 2012

• All items in category Genetics and Vitamin D items

• Search VitaminDWiki for Fok1 91 items as of Feb 2017

• Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017

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