Omega-3 increases Vitamin D levels – Meta-analysis
The influence of omega-3 supplementation on vitamin D levels in humans: a systematic review and dose-response meta-analysis of randomized controlled trials
Critical Reviews in Food Science and Nutrition Vol 62, 2022 - Issue 11 Pages 3116-3123 | online: 25 Dec 2020
Habeeb Alhabeeb,Hamed Kord-Varkaneh,Shing Cheng Tan,Mihnea-Alexandru Găman,Bander Yayha Otayf, Almuhannad Ali Qadri,
Need at least 1000 mg of Omega-3
Omega-3 increased Vitamin D by 20% if Vitamin D <12 ng or >37 ng
Background
Inconsistencies exist with regard to the influence of omega-3 supplementation on 25-hydroxyvitamin D (25(OH)D) levels, which could be attributed to many factors, such as the duration and dose of omega-3 supplementation, and individuals’ baseline 25(OH)D levels. Therefore, to address the inconsistencies, we conducted a systematic review and dose-response meta-analysis to accurately determine the effect of omega-3 supplementation on 25(OH)D levels in humans.
Methods
We performed a comprehensive literature search in Web of Science, PubMed/Medline, Scopus, and Embase databases from inception up to January 2020. We included only randomized controlled trials (RCTs). We used weighted mean difference (WMD) with 95% confidence interval (CI) to assess the influence of omega-3 supplementation on serum 25(OH)D levels using the random-effects model.
Results
Our pooled results of 10 RCTs demonstrated an overall significant increase in 25(OH)D levels following omega-3 intake (WMD = 3.77 ng/ml, 95% CI: 1.29, 6.25). In addition, 25(OH)D levels were significantly increased when the intervention duration lasted >8 weeks and when the baseline serum 25(OH)D level was ˂20 ng/ml. Moreover, omega-3 intake ≤1000 mg/day resulted in higher 25(OH)D levels compared to omega-3 intake >1000 mg/day.
Conclusion
In conclusion, omega-3 supplementation increased 25(OH)D concentrations, particularly with dosages ≤1000 mg/day and intervention durations >8 weeks.
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Omega-3 index measurement in blood is a far better measure than Omega-3 consumption
Suspect far larger increase if they had considered only those with Omega-3 index > 6
VitaminDWiki pages with OMEGA-3 INDEX in title (21 as of March 2024)
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VitaminDWiki Omega-3 category pages with VITAMIN in title (139 as of March 2024)
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