Omega-3 greatly reduced sleep deprivation problems in rats

The role of omega-3 on modulation of cognitive deficiency induced by REM sleep deprivation in rats

Behavioural Brain Research. online 2 June 2018, https://doi.org/10.1016/j.bbr.2018.06.002

Mohammad Nasehia, nasehi@iricss.org, , Seyed Moslem Mousavi Nezhadb, Fatemeh Khakpaia, Mohammad-Reza Zarrindastc, d, e, ,

Started with Omega-3 injection of rats for 3 days | | | | --- | --- | | milligrams/ 10 grams of body weight | grams if body weight = 80 kg | | 0.25 | 2 gram | | 0.5 | 4 gram | | 1.0 | 8 gram | | 1.25  | 10 gram | for some tests 1.25 was uniquely good, for some tests 1.25 was also good, for some tests 1.25 was uniquely bad Then Fear Conditioning Then Deprived rats of REM sleep Then tested Performance A few of the results --- 1. See also VitaminDWiki Items in both categories Sleep and Omega-3 are listed here: {category} --- 1. See also web * [Search web for “Sleep Deprivation “ OMEGA-3](https://www.google.com/search?num=20&source;=hp&ei;=RgMdW7zSGrzB0PEPlJWSwAo&q;=%22sleep+deprivation%22+omega-3+&oq;=%22sleep+deprivation%22+omega-3+&gs;_l=psy-ab.3..0i22i30k1.2313.2313.0.3308.3.2.0.0.0.0.373.373.3-1.2.0....0...1..64.psy-ab..1.2.591.6..35i39k1.220.sjzZ6jcmoOg) 400,000 Hits June 2018 * Mitigating Sleep Deprivation with Omega-3 Fatty Acids 2015 ? * Mitigating Sleep Loss: Assessment of Omega-3 fatty acids US Military – 2011 free PDF

PDF is with great charts is available free at Sci-Hub

Highlights

•Omega-3 showed dual effect on context- or auditory-dependent fear memory.

•Intravenously administration of omega-3 induced anxiolytic-like behaviors.

•Depression-like behaviors decreased by injection of omega-3.

•Administration of omega-3 produced anti-nociceptive responses.

•Omega-3 plays main role in cognitive deficiencies induced by RSD.

Prolonged sleep deprivation causes cognitive deficits. In rats, for instance, sleep deprivation weakens spatial learning and long-term potentiation (LTP). We examined the effects of omega-3 on cognitive deficiency induced by REM sleep deprivation (RSD). For this purpose, we used a fear conditioning paradigm, forced swim test (FST) apparatus, and hot plate test. Intravenously omega-3 injection was performed during 3 consecutive days. Rats trained in the fear conditioning apparatus after 24 hours. During conditioning, animals were received foot shocks, either alone or paired with a sound. Sleep deprivation paradigm was carried out in which REM sleep was completely prevented and non-REM sleep was intensely declined for 24 hours. Then, context-dependent retention, anxiety behaviors, and hot plate tests were done. Auditory-dependent retention, anxiety behaviors, and FST were carried out 24 hours later. 24 hours of RSD impaired cognitive function, however intravenously administration of omega-3 improved (0.25, 0.5 and 1 mg/kg) context- or auditory-dependent memory, induced anxiolytic (1 mg/kg), antidepressant (1.25 mg/kg), and anti-nociceptive (0.25 mg/kg) effects. The results revealed that RSD interferes with the neural systems underlying cognitive functions and supports the involvement of omega-3 in the modulation of cognitive functions.