Off Topic: Smaller people may live longer due to more benefit from supplements and drugs

Hypothesis: The same pill (Vitamin D, multivitamin, drug) is likely to have 2X the affect if the person weighs 1/2 as much. It probably does not matter if the pill is for prevention or treatment

Note: smaller people includes both

• shorter in height

• same height but less weight/BMI

See also VitaminDWiki

• Overview Veterinary and vitamin D Most animal supplements are computed per pound of animal weight
  • A vet does not give a fixed amount to a cat, but rather bases the drug amount on weight of cat

• Obese need more Vitamin D: Volume dilution, IU per pound, or BMI – RCT Dec 2012

• Obese need 2X as much vitamin D to get the same response – June 2012

• Higher BMI need more vitamin D – Oct 2010

See also web

• Small People’s Longevity Vitamin D Survivor Feb 2013 (the inspiration for this web page)
  • ‘’It seems in the grand wisdom of the examiners that a small one year old child needs for vitamin D are the same as a sixty year old two hundred fifty pound man – 800IU per day’’
  • ‘’ Rule of thumb for vitamin D: Forty IU of D3 per pound of body weight per day . . . ’’
• Body weight and longevity. A reassessment. JAMA 1987
  • ‘’ The shape of the curve relating weight to all-cause mortality has been variously described as linear, J-shaped, and even U-shaped’’
  • Many problems with previous studies:
  •        failure to control for cigarette smoking,
  •        inappropriate control of biologic effects of obesity, such as hypertension and hyperglycemia, and
  •        failure to control for weight loss due to subclinical disease
  • available evidence suggests that minimum mortality occurs at relative weights at least 10% below the US average.
• Advantages of Shorter Height
  • It is a review of the book: Human Body Size and the Laws of Scaling: Physiological, Performance, Growth, Longevity and Ecological Ramifications – 2007
  • Has extensive bibliography
• Search web: magnesium "pound of body weight"
  • 3, 6, and up to 10 mg of Mg per pound of body weight on the web
  • 410 mg of Magnesium is the US RDA for adult male – independent of body weight
• Nurses know to compute infant dosage based on body weight
  • Wonder why adult doses are not based on weight
• Zinc
  • 1 mg Zinc per pound of body weight.
  • Merck Manual Recommended Dietary Allowance = 0.44 mg/pound = 66 mg for 150 lb person
  • US Recommended Daily Amount = 15 mg
  • Big confusion between the two different RDAs