Non-alcoholic fatty liver disease associated with much lower vitamin D

Created April 2015

The association of vitamin D deficiency with non-alcoholic fatty liver disease.

Clinics (Sao Paulo). 2014 Aug;69(8):542-6.

Küçükazman M1, Ata N2, Dal K2, Yeniova AÖ1, Kefeli A1, Basyigit S1, Aktas B1, Akin KO3, Ağladıoğlu K4, Üre ÖS2, Topal F5, Nazligül Y1, Beyan E2, Ertugrul DT6.

Author information

1Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.

2Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.

3Department of Clinical Biochemistry, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.

4Department of Radiology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.

5Department of Gastroenterology, Ankara Oncology Teaching and Research Hospital, Ankara, Turkey.

6Department of Endocrinology and Metabolism, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.

Good Vitamin D blood levels require healthy liver and kidney NAFLD is an indication of an unhealthy liver See also VitaminDWiki Overview Liver and vitamin D contains the following summary {include} Strong association of non alcoholic fatty liver disease and low vitamin D 📄 Download the PDF from VitaminDWiki

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OBJECTIVE:

Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease.

METHODS:

We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty liver disease and 154 had non-alcoholic fatty liver disease.

RESULTS:

The non-alcoholic fatty liver disease group had significantly higher fasting blood glucose (p = 0.005), uric acid (p = 0.001), aspartate aminotransferase (p<0.001), alanine aminotransferase (p<0.001), γ-glutamyltransferase (p<0.0001), alkaline phosphatase (p = 0.028), HbA1c (p<0.001), ferritin (p<0.001), insulin (p = 0.016), C-peptide (p = 0.001), HOMA-IR (p = 0.003), total cholesterol (p = 0.001), triglyceride (p = 0.001) and white blood cell (p = 0.04) levels. In contrast, the non-alcoholic fatty liver disease group had significantly lower 25(OH)D levels (12.3±8.9 ng/dl, p<0.001) compared with those of the control group (20±13.6 ng/dl).

CONCLUSIONS:

In this study, we found lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease than in subjects without non-alcoholic fatty liver disease. To establish causality between vitamin D and non-alcoholic fatty liver disease, further interventional studies with a long-term follow-up are needed.

PMID: 25141113

Tags: Liver