Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)

Created February 2017

Vitamin D receptor gene polymorphisms are associated with multiple sclerosis in Mexican adults

Journal of Neuroimmunology, online 3 February 2017

Víctor Hugo Bermúdez-Moralesa, Geny Fierrosa, Roberto Lopez Lopeza, Gaby Martínez-Navaa,

Mario Flores-Aldanab, José Flores-Riverac, Carlos Hernández-Girónd, ,

a National Institute of Public Health, Colonia Santa Maria Ahuacatitlan, Cuernavaca, Morelos CP 62100, Mexico

b Nutrition and Health Research Center, National Institute of Public Health, Colonia Santa Maria Ahuacatitlan, Cuernavaca, Morelos CP 62100, Mexico

c Department of Neurology, National Institute of Neurology and Neurosurgery, Avenida Insurgentes Sur 3877, Ciudad de México, D.F. CP 3877, Mexico

d Department of Epidemiology, Population's Health Research Center, National Institute of Public Health, Colonia Santa Maria Ahuacatitlan, Cuernavaca, Morelos CP 62100, Mexico

* Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies Iran * Health problems that run in families are often associated with low vitamin D * Overview MS and vitamin D * Multiple Sclerosis and Vitamin D ~ 50,000 Facebook members in 13 languages – Jan 2017 1. # The articles in both MS and Genetics are: {category} 1. # The articles in both MS and Vitamin D Receptor are: {category} 1. # Vitamin D Receptor category has the following {include} * * *One MS "cure" uses very large doses of Vitamin D ✻If people knew when they have a poor VDR they should be able to just take more Vitamin D to grealy reduce their chance of MS, etc ✻Note: A low-cost VDR test exists - see above* *

Background

Multiple sclerosis (MS) is the most prevalent autoimmune inflammatory demyelinating disease of the central nervous system (CNS) in young adults. More than 50 genomic regions have been associated with MS susceptibility.

Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms – which interfere with the actions of Vitamin D- could be related to increased risk of MS.

Methods

We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez in Mexico City. Genotyping of VDR gene polymorphisms BsmI (rs1544410) and TaqI (rs731236) was performed using TaqMan SNP Genotyping Assay which consists of a predesigned mix of unlabeled polymerase chain reaction (PCR) primers and the TaqMan minor groove binding group (MGB) probe (FAM dye-labeled).

Results

There was a statistically significant, positive association between MS and the T/T genotype of BsmI polymorphism ( OR = 4.15 ; 95%CI 1.83–9.39), showing also a significant positive trend across genotypes (p < 0.01).

This association was also present evaluating the recessive inheritance model of the polymorphism ( OR = 3.91 ; 95%CI 1.77–8.64). When evaluating the association by alleles, the statistically significant positive association seen by genotypes was confirmed in the T allele carriers, showing an OR of 1.83 (95%CI 1.27–2.65) for MS.

Conclusions

We found a positive association of the genetic VDR polymorphisms TaqI (rs731236) and BsmI (rs1544410), with the risk of MS in a sample of Mexican adults.

Tags: Multiple Sclerosis Vit D Receptor