Multiple Sclerosis helped by UV – possibly via cytokines, etc.

Ultraviolet radiation, vitamin D and multiple sclerosis.

Neurodegener Dis Manag. 2015 Oct;5(5):413-24. doi: 10.2217/nmt.15.33. Epub 2015 Oct 19.

Lucas RM 1,2, Byrne SN 3, Correale J 4, Ilschner S 5, Hart PH2.

1National Centre for Epidemiology & Population Health, Research School of Population Health, The Australian National University, Canberra, Australia.

2Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.

3Sydney Medical School, University of Sydney, Sydney, Australia.

4Department of Neurology, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.

5Independent researcher.

* Overview MS and vitamin D * Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 * Anti-inflamatory cytokines increased when vitamin D levels were raised above 30 ng – RCT Feb 2015 * Pro-inflammatory cytokines cause the 74 percent drop in vitamin D after knee arthroplasty – Feb 2014 * The sun provides more health benefit than vitamin D – Dr. Lucas podcast – May 2015 The items in both categories MS and UV are listed here: {category} The items in both categories MS and Inflammation are listed here: {category}

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There is compelling epidemiological evidence that the risk of developing multiple sclerosis is increased in association with low levels of sun exposure, possibly because this is associated with low vitamin D status. Recent work highlights both vitamin D and non-vitamin D effects on cellular immunity that suggests that higher levels of sun exposure and/or vitamin D status are beneficial for both MS risk and in ameliorating disease progression.

Here we review this recent evidence, focusing on regulatory cells, dendritic cells, and chemokines and cytokines released from the skin following exposure to ultraviolet radiation.

KEYWORDS: B regulatory cells; cis-urocanic acid; dendritic cells; multiple sclerosis; ultraviolet radiation; vitamin D

PMID: 26477548 DOI: 10.2217/nmt.15.33