Multiple Sclerosis depression reduced by 10,000 IU of vitamin D

Created February 2019

Effect of vitamin D replacement on depression in multiple sclerosis patients.

Mult Scler Relat Disord. 2019 Jan 23;29:111-117. doi: 10.1016/j.msard.2019.01.029.

Kotb MA1, Kamal AM2, Aldossary NM3, Bedewi MA3.

Note: Getting a lot more Vitamin D actually cures MS * Comparing High-dose vitamin D therapies * Overview MS and vitamin D * Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 Intervention of Vitamin D for Depression {category} Meta-analyses of Vitamin D and Depression {category} Depression category listing has items along with related searches

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MS Depression - baseline

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MS Depression after 8 months (note the change of scales)

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BACKGROUND:

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Depression is common among MS patients. In patients without MS, lower vitamin D levels were associated with higher depression scores and severity. Supplementation of vitamin D was associated with significant improvement of depressive symptoms.

OBJECTIVE: to evaluate the relation between vitamin D levels and depression scores, and the effect of vitamin D replacement on the depressive symptoms in patients with MS.

METHODS:

The study included 35 patients with relapsing remitting multiple sclerosis. Neurological, psychiatric, and radiological evaluations were done. Participants received 10,000 IU of cholecalciferol daily for 12 months.

RESULTS:

Vitamin D level was low at baseline. Depressive symptoms were high at baseline and improved with vitamin D replacement although, Expanded Disability Status Scale (EDSS) score was not improving. Vitamin D levels correlated negatively with depressive symptoms at baseline and follow up periods.

CONCLUSION:

Lower vitamin D levels are associated with higher depressive scores, and vitamin D replacement could improve depressive symptoms in patients with relapsing remitting multiple sclerosis.

Tags: Depression Multiple Sclerosis