More COVID mortality if less than 20 ng of Vitamin D (Mexico)
Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19
Erick J. Martínez-Rodríguez1*, Juan Gutiérrez-Mejía1, Camilo Ríos-Castañeda2, Sonia Rojas-Maya3, Adrián Soto-Mota1
Gac Med Mex. 2022;158:31-35
1Department of Hospital Reaction for Disasters, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”;
2Neurochemistry Department, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”;
3Clinical Laboratory Department, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”. Mexico City, Mexico
- Correspondence: Erick J. Martínez-Rodríguez. E-mail: erickmarrod99@gmail.com
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Introduction: One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome.
Objective: To evaluate the usefulness of vitamin D for predicting mortality in patients with COVID-19.
Methods: Observational, retrospective study in which 154 patients diagnosed with COVID-19 were included, out of whom 111 survived and 43 died. Vitamin D concentration was determined in all of them.
Results: A log-rank p-value < 0.032 was obtained for survival when vitamin D concentration was used as a categorical variable (≤ 20 ng/mL and > 20 ng/mL). On Cox proportional analysis, age and vitamin D concentration were shown to be risk factors associated with mortality in patients with COVID-19 (age: HR = 1.036, 95% CI = 1.016-1.058, p < 0.001; vitamin D: HR (≤ 20 ng/mL and > 20 ng/mL) = 0.478, 95% CI = 0.237-0.966, p < 0.040).
Conclusion: Age and vitamin D concentration were predictive factors for mortality in COVID-19-infected patients.
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