Migraine headaches treated by Vitamin D – meta-analysis

Created January 2021

The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies

Clin Neuropharmacol. 2021 Jan-Feb 01;44(1):5-8. doi: 10.1097/WNF.0000000000000419.

Yuan-Feng Zhang 1, Zhi-Qiang Xu, Hong-Jie Zhou, Ya-Zhen Liu, Xiao-Jiang Jiang

Headache has the following on metals and migraines {include} --- Migraines have low vitamin D, Migraines plus Restless Leg have far lower vitamin D (no surprise) – Dec 2021

Introduction: The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients.

Methods: We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model.

Results: Five randomized controlled trials are included in the meta-analysis. Overall, compared with control group in migraine patients, vitamin D treatment is associated with

  • substantially reduced number of headache days

    • (standard mean difference [SMD], -0.53; 95% confidence interval [CI], -0.83 to -0.23; P = 0.0006),

  • frequency of headache attacks (SMD, -1.09; 95% CI, -1.86 to -0.32; P = 0.006),

  • headache severity (SMD, -0.55; 95% CI, -0.91 to -0.19; P = 0.0003), and

  • Migraine Disability Assessment score (SMD, -0.76; 95% CI, -1.11 to -0.40; P < 0.0001).

Conclusions: Vitamin D treatment is effective to alleviate migraine.

References

  • Ghorbani Z, Togha M, Rafiee P, et al. Vitamin D in migraine headache: a comprehensive review on literature. Neurol Sci 2019;40(12):2459–2477.

  • MacGregor EA. Migraine. Ann Intern Med 2017;166(7):ITC49–ITC64.

  • Schwedt TJ. Chronic migraine. BMJ 2014;348:g1416.

  • Dodick DW, Silberstein SD, Lipton RB, et al. Early onset of effect of onabotulinumtoxinA for chronic migraine treatment: analysis of PREEMPT data. Cephalalgia 2019;39:945–956. 333102418825382.

  • Mattle HP, Nedeltchev K, Schankin C, et al. Migraine Headache: Clinical Association With PFO and Observational Studies, Patent Foramen Ovale Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia. Elsevier; 2020:117–127.

Tags: Headache Meta-analysis