Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT

Effect of Vitamin D supplementation on symptoms and C-reactive protein in migraine patients

Journal of Research in Medical Sciences

Tayebeh Mottaghi, Gholamreza Askari, Fariborz Khorvash, Mohammad Reza Maracy

Background: Migarine is the most common headache around the world including Iran. In recent years, Vitamin D deficiency has been shown to a global health problem. A few studies have been determined inverse association between serum levels of Vitamin D with a headache. So, in this study, we investigated the effect of Vitamin D supplementation on symptoms and C-reactive protein(CRP) among patients with migraine.

Materials and Methods: This study was randomized, double-blind, and controlled-placebo clinical trial. Sixty-five migraine patients aged 10-61 years were included for analysis. Vitamin D was administrated for 10 weeks with 50,000 IU dosage of Vitamin D per week. Multivariate analysis of covariate and univariate analysis of covariate were done to determine the effects of Vitamin D supplementation on symptoms, including severity, duration, frequency of headache, and the headache diary result (HDR).

Results: Mean headache frequency and HDR had significant difference among two groups (5.9 ± 7.0 vs. 7.0 ± 6.0, P = 0.06 and 85.0 ± 134.2 vs. 132.1 ± 147.1, P = 0.04). But, a mean difference of headache frequency was marginally significant (P = 0.06). These values were lower among the intervention group compared to placebo group. The association was not observed between CRP with migraine disease.

Conclusion: In this study, we shown Vitamin D supplementation may be useful in decreasing frequency of headache attacks and HDR among patients with migraine.

See also VitaminDWiki

Headaches helped by Vitamin D in 7 studies – Jan 2020

Pages listed in BOTH the categories Headache and Magnesium

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• Headache category listing has items along with related searches which has the following

  Migraine Headaches associated with metal excess/deficiencies - July 2015

Compared blood levels of 25 with migraines to 25 without

• Zinc and Vitamin D category listing has items along with related searches

  Speculation by VitaminDWiki

  Significant migraine reduction if use 10,000 IU of vitamin D, Magnesium, and perhaps Zinc

• Cadmium liver problem 5 X less likely when vitamin D is greater than 40 ng – April 2018

  • The study found 5X fever Cadium lever problems with vitamin D > 40 ng

See also web

• Vitamin D supplementation may help patients with migraines, according to RCT
  • Vitamin D Council on this same study