Vitamin D Supplementation and the Risk of Infections in Fullterm Infants.

Correlations with the Maternal Serum Vitamin D – Poster # 896

Arch Dis Child 2012;97:A257 doi:10.1136/archdischild-2012-302724.0896

The 4th Congress of the European Academy of Paediatric Societies, 5–9 October 2012. Istandul, Turkey

AAM El-Mazary, M Abdel-Maaboud, M Mohamed, K Nasef

Minia University Hospital, Minia City, Egypt

Vitamin D insufficiency has been linked with susceptibility to infection, autoimmune diseases and cancers.

Objective To study the effect of vitamin D supplementation on the immunity and the risk of infections during the first year of life in full term infants.

Methods This is a prospective case control study included 99 full term infants attending Minia university hospital during the period from January 2010 to February 2012. They were divided into two groups: group I included forty-eight full term infants supplemented with daily 400 I.U vitamin D for 6-months after birth and group II included fifty-one full term infants not supplemented with vitamin D. History taking and clinical examination and other investigations needed for diagnosis of respiratory, GIT and urinary tract infections were addressed every visit for one year.

Results The incidences of infections totally were less common in infants supplemented with vitamin D than those not supplemented (p-value = 0.01).

• Otitis media, p-value = 0.003,

• bronchiolitis, p-value =0.001

• pneumonia, p-value =0.001

• gastroenteritis, p-value =0.01

were less common in them.

There were no significant differences as regards urinary tract infections between the two groups (p=0.3). significant negative correlations between respiratory and GIT infections and the maternal vitamin D levels were present.

Conclusions Vitamin D supplementation decreased the incidence of infections especially respiratory and GIT infections.

Maternal vitamin D levels correlated negatively with the incidence of infections.

See also VitaminDWiki

• All items in category Immunity and Vitamin D items

• An update on vitamin D and human immunity – March 2012

• Cow, mouse, and human immune system and vitamin D – March 2012

• Immune system and vitamin D patent 2008

• Vitamin D helps T-cell and immune system – overview Aug 2011

• 6400 IU vitamin D is effective during breastfeeding – Oct 2010

• Only about 10 percent of breastfed infants get even the minimum recommended vitamin D – April 2010

• All items in Infant-Child items

• Many infant infections avoided with supplementation with 400 IU of vitamin D – Oct 2012

• Breastfed without vitamin D supplements – a problem for NZ infants Jan 2013

• Middle ear infection (Otitis Media) and Vitamin D – many studies