Iron increased slightly by small amount of Vitamin D for a short time – RCT

Created March 2019

Salma F Ahmad Fuzi1 2, Sohail Mushtaq1

From the Faculty of Medicine, Dentistry and Life Sciences, University of Chester, Parkgate Road, Chester, UK, CHI 4BJ
From the Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Address correspondence to Associate Professor Sohail Mushtaq, Faculty of Medicine, Dentistry and Life Sciences, University of Chester, Parkgate Road, Chester, UK, CHI 4BJ. Tel: +44 (0)124 4513367, Fax: +44 (0)124511310, Email address: s.mushtaq@chester.ac.uk

Iron added to cereal for 27 year-old women Half of them got 1500 IU Vitamin D daily, but for only 8 weeks Expect far better results if dose and duration had been increased for example:3,000 IU for 15 weeks --- 1. See also VitaminDWiki * Iron and Vitamin D deficiencies are synergistic - April 2015 * Overview Iron Supplements and Vitamin D * Vitamin D deficiency 2.5 X more likely in iron-deficient children – Dec 2018 * Autistic children have lower levels of Iron, Vitamin D, Magnesium, etc – Oct 2017 * Breastfed infants 6 times more likely to deficient in Vitamin D and Iron – Aug 2015 1. # Items in both categories Iron and Women are listed here: {category} 1. # Items in both categories Iron and Pregnancy are listed here: {category}

ABSTRACT

The effect of 38 pg (1500 IU) daily vitamin D3 supplementation, consumed with an iron-fortified

breakfast cereal for 8 weeks, on haematological indicators in iron-deficient female subjects was

investigated. Fifty iron-deficient subjects (plasma ferritin concentration < 20 pg/L; mean age ± SD:

27.4 ± 9.4 years) were randomised to consume an iron-fortified breakfast cereal containing 9 mg of

iron daily, with either a vitamin D3 supplement or placebo. Blood samples were collected at

baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of iron and vitamin D

status biomarkers. The effect of intervention was analysed using mixed-model repeated measures

ANOVA. Significant increases were observed in two main haematological indices: haemoglobin

concentration and haematocrit level from baseline to post-intervention in the vitamin D group, but

not in the placebo group. The increase from baseline to post-intervention in haemoglobin

concentration in the vitamin D group (135 ± 11 to 138 ± 10 g/L) was significantly higher compared

to the placebo group (131 ± 15 to 128 ± 13 g/L) (P=0.037). The increase in haematocrit level from

baseline to post-intervention was also significantly higher in the vitamin D group (42.0 ± 3.0 to 43.8

± 3.4%) compared to the placebo group (41.2 ± 4.3 to 40.7 ± 3.6%) (P=0.032). Despite the non-

significant changes in plasma ferritin concentration, this study demonstrates that 38 pg

supplemental vitamin D, consumed daily, with iron-fortified breakfast cereal led to improvement in

haemoglobin concentration and haematocrit levels in women with low iron stores. These findings

may have therapeutic implications in the recovery of iron status in iron-deficient populations at a

healthcare level.

Tags: Iron Women