Hypothesis: Vitamin D is the link between Osteoporosis, Obesity, and Diabetes

Vitamin D: Link between Osteoporosis, Obesity, and Diabetes?

Int. J. Mol. Sci. 2014, 15(4), 6569-6591; doi:10.3390/ijms15046569 (doi registration under processing)

Flávia Galvão Cândido flaviagcandido@hotmail.com and Josefina Bressan

Laboratory of Body Composition and Energy Metabolism, Departamento de Nutrição e Saúde-CCB II, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n, Viçosa, MG 36570-900, Brazil

(This article belongs to the Section Bioactives and Nutraceuticals)

Vitamin D (1,25(OH)2D3) is a steroid hormone that has a range of physiological functions in skeletal and nonskeletal tissues, and can contribute to prevent and/or treat osteoporosis, obesity, and Type 2 diabetes mellitus (T2DM). In bone metabolism, vitamin D increases the plasma levels of calcium and phosphorus, regulates osteoblast and osteoclast the activity, and combats PTH hypersecretion, promoting bone formation and preventing/treating osteoporosis. This evidence is supported by most clinical studies, especially those that have included calcium and assessed the effects of vitamin D doses (≥800 IU/day) on bone mineral density. However, annual megadoses should be avoided as they impair bone health.

Recent findings suggest that low serum vitamin D is the consequence (not the cause) of obesity and the results from randomized double-blind clinical trials are still scarce and inconclusive to establish the relationship between vitamin D, obesity, and T2DM.

Nevertheless, there is evidence that vitamin D

• inhibits fat accumulation,

• increases insulin synthesis and

• preserves pancreatic islet cells,

• decreases insulin resistance and

• reduces hunger, favoring obesity and T2DM control.

To date, there is not enough scientific evidence to support the use of vitamin D as a pathway to prevent and/or treat obesity and T2DM.

Figure 2

📄 Download the PDF from VitaminDWiki

See also VitaminDWiki

• Overview Osteoporosis and vitamin D

• Overview Diabetes and vitamin D

• 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013

  • The Osteo doctors did not tell the patients, they found out for themselves
  • Do not expect a doctor to recommend a pill which will eliminate his job (vitamin D)
• Diseases that may be related via low vitamin D has the following chart

Pages listed in BOTH Obesity AND Diabetes

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Pages listed in BOTH Meatabolic Syndrome AND Diabetes

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Pages listed in BOTH Osteoporosis AND Diabetes

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See also web

• nternational Osteoporosis Foundation (IOF) Bone and Diabetes Scientific Working Group Dec 2015
  • 6 X increased risk of broken bones in patients with type 1 diabetes
  • Their study only mentions use of 1,000 IU of vitamin D - which is far too little to make a difference
  • 📄 Download the PDF from VitaminDWiki