Gut bacteria of Crohn's disease patients improved by Vitamin D

Created May 2018

Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls

Journal of Digestive Diseases Volume 19, Issue 4, published: 23 March 2018

https://doi.org/10.1111/1751-2980.12591

Holger Schäffler Daniel PR Herlemann Paul Klinitzke Peggy Berlin Bernd Kreikemeyer Robert Jaster Georg Lamprecht

* From PDF Cholecalciferol 20.000 IU daily from day 1 until day 3, then every second day for 4 weeks. In this study, we aimed for a target vitamin D level between 100 and 150 nmol/l. Serum 25-OH vitamin D levels were measured weekly (before administration = week 0). In both groups, 380.000 IU 25-OH vitamin D were administered per patient over the course of the study * Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 --- Overview Gut and vitamin D has the following summary {include} --- Gut category listing contains the following {include}

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OBJECTIVE

Dysbiosis is a common feature in the pathogenesis of inflammatory bowel diseases (IBD). Environmental factors, such as vitamin D deficiency, seem to play a role in the intestinal inflammation of IBD. The aim of this study was to investigate whether vitamin D administration has an impact on the bacterial composition in Crohn's disease (CD) compared to healthy controls (HC).

METHODS

A prospective, longitudinal, controlled interventional analysis was conducted in seven patients with CD in clinical remission and 10 HC to investigate the effect of orally administrated vitamin D on the intestinal bacterial composition using 16S ribosomal RNA gene amplicon sequencing. Clinical parameters were assessed.

RESULTS

In contrast to HC, microbial communities of CD patients changed significantly during early vitamin D administration. However, a further increase in vitamin D level was associated with a reversal of this effect and additionally with a decrease in the bacterial richness in the CD microbiome. Specific species with a high abundancy were found during vitamin D administration in CD, but not in HC; the abundancy of Alistipes, Barnesiella, unclassified Porphyromonadaceae (both Actinobacteria), Roseburia, Anaerotruncus, Subdoligranulum and an unclassified Ruminococaceae (all Firmicutes) increased significantly after 1‐week vitamin D administration in CD.

CONCLUSIONS

Vitamin D has a specific influence on the bacterial communities in CD, but not in HC. Administration of vitamin D may have a positive effect in CD by modulating the intestinal bacterial composition and also by increasing the abundance of potential beneficial bacterial strains.