Feldman and Pike’s Vitamin D book - 5th Edition

Created November 2023

5th edition 2023 $187 for hardback or PDF

Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease.

Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including sports medicine, opthalmology, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.

Chapters 1 - 50 (Vol 1)

  • 1. Book introduction: Major trends in vitamin D research

  • 2. Evolution of human skin pigmentation and vitamin D

  • 3. Photobiology of vitamin D

  • 4. The activating enzymes of vitamin D metabolism (25- and 1a-hydroxylases)

  • 5. CYP24A1: structure, function, and physiological role

  • 6. Alternative pathways for vitamin D metabolism

  • 7. Vitamin Debinding protein

  • 8. Regulation of renal vitamin D metabolism

  • 9. Regulation of extra-renal synthesis of 1,25(OH)2D

  • 10. Structural basis for ligand activity in vitamin D receptor

  • 11. Genome-wide perspectives on vitamin D receptor actions

  • 12. Vitamin D, chromatin, and epigenetics

  • 13. The diverse genomic mechanisms of action of the vitamin D receptor

  • 14. Vitamin D and microRNAs

  • 15. Pathway based-analysis of transcriptomic data from vitamin D studies

  • 16. Vitamin D and the kidney

  • 17. Vitamin D and the calcium-sensing receptor

  • 18. Regulation of intestinal calcium and phosphate absorption by vitamin D

  • 19. Vitamin D and FGF23 20. Osteoclastogenesis and vitamin D

  • 21. Vitamin D activity in osteoblasts and osteocytes

  • 22. Cartilage

  • 23. Vitamin D and bone: an integrated approach

  • 24. Vitamin D in dentoalveolar and oral health

  • 25. Role of vitamin D in skin and hair biology

  • 26. Vitamin D and the cardiovascular system

  • 27. Vitamin D, brain development and function

  • 28. Vitamin D, VDR, and adipose tissue: focus on cellular mechanisms

  • 29. Vitamin D and skeletal muscle

  • 30. Understanding vitamin D from mouse knockout models

  • 31. Pharmacology and pharmacokinetics of vitamin D

    • https://doi.org/10.1016/B978-0-323-91386-7.00007-6: This chapter describes the metabolic parameters of vitamin D and its metabolites according to the framework of pharmacokinetics. The pharmacokinetics of vitamin D is considerably more complex than a standard pharmacological agent, because of the required stepwise hydroxylation into the active form, 1,25(OH)2D, its endogenous, cutaneous synthesis, and presence of vitamin D and its metabolites in the circulation and tissues. Also, its binding to the vitamin D–binding protein (DBP) influences the properties of the vitamin D metabolites. These aspects are discussed throughout this chapter. The absorption, distribution, dose-response, metabolism, excretion, and toxicity of vitamin D and its metabolites are reviewed. In addition, we present the current knowledge of factors influencing 25-hydroxyvitamin D half-life, the influence of DBP on vitamin D metabolism, and the differences in pharmacokinetics between bound and free 25-hydroxyvitamin D.

  • 32. Vitamin D as a modifier of genomic function and phenotypic expression during pregnancy

  • 33. The role of vitamin D physiology in regulating calcium and bone metabolism in mother and child: pregnancy, lactation, postweaning, fetus, and neonate

  • 34. Vitamin D and the placenta

  • 35. Consequences of perinatal vitamin D deficiency on later bone health

  • 36. Adolescence and acquisition of peak bone mass

  • 37. The role of vitamin D in orthopedic surgery

  • 38. Vitamin D and muscle performance in athletes and older adults

  • 39. Role in reproductive biology and dysfunction in women

  • 40. Vitamin D, reproductive endocrinology,

  • and male reproductive organ function in health and disease

  • 41. Vitamin D and the renineangiotensin system

  • 42. Vitamin D: presence and function in the eye

  • 43. Adult vitamin D deficiency and adverse brain outcomes

  • 44. Vitamin D and the lung

  • 45. Design and synthesis of vitamin D analogs

  • 46. Structure function relationships of VDR ligands

  • 47. Modulating vitamin D receptore coregulator binding with small molecules

  • 48. Mass spectrometry assays of vitamin D metabolites

  • 49. Measurement and quality assessment of total and free 25-hydroxyvitamin D

  • 50 Vitamin D tissue distribution by mass spectrometry imaging

Chapters 51- 106 (vol II)

  • 51. Defining thresholds for vitamin D I: scientific rationale for serum 25-hydroxyvitamin D cutoffs of 25 and 50nmol/L

  • 52. Defining thresholds for vitamin D II

  • 53. Methods of evaluating population studies of vitamin D: strengths and weaknesses

  • 54. Worldwide vitamin D status

  • 55. Vitamin D in food—Compounds, stability, sources

  • 56. Determinants of vitamin D levels from sun exposure: a global perspective inVitaminDWiki

  • 57. Vitamin D supplement use as a public health strategy to augment diet and sustain population adequacy

  • 58. Vitamin D and food fortification

  • 59. Bariatric surgery, vitamin D, and bone loss

  • 60. Genetic determinants of 25-hydroxyvitamin D concentrations

  • 61. Effect of vitamin D on health and disease: evidence from Mendelian randomization

  • 62. Growth plate histology, bone histomorphometry, and radiologic features of nutritional rickets and osteomalacia

  • 63. Vitamin D deficiency and nutritional rickets in infants and children

  • 64. Clinical disorders of phosphate homeostasis

  • 65. The hypocalcemic disorders

  • 66. Vitamin D hydroxylation–deficient rickets, type 1A

  • 67. The role of genetic variation in CYP2R1, the principal vitamin D 25-hydroxylase, and CYP3A4 in vitamin D homeostasis

  • 68. Hereditary 1,25-dihydroxyvitamin D resistant rickets (VDDR-2A)

  • 69. Infantile hypercalcemia and CYP24A1 mutations

  • 70. Vitamin D and osteoporosis

  • 71. Adult vitamin D deficiency—fracture and fall prevention: findings from randomized controlled trials

  • 72. Randomized clinical trials of vitamin D and bone health

  • 73. Calcifediol as a therapeutic

  • 74. Vitamin D and organ transplantation

  • 75. Vitamin D, obesity, the metabolic syndrome and its sequelae

  • 76. The role of vitamin D in type 2 diabetes

  • 77. Liver metabolism and disease

  • 78. Vitamin D, hypertension, and cardiovascular disease

  • 79. Vitamin D and renal disease

  • 80. Vitamin D and kidney stones

  • 81. Hypercalcemia due to vitamin D toxicity

  • 82. Vitamin D and Paget's disease

  • 83. Vitamin D metabolism and disorders in companion animals

  • 85. Vitamin D status and cancer incidence, mortality, and prognosis

  • 86. Antiproliferative and immunoregulatory actions of vitamin D derivatives on hematological malignancies: control of differentiation, proliferation, and cell death

  • 87. Vitamin D, inflammation, and cancer

  • 88. Vitamin D actions in mammary gland and breast cancer

  • 89. Vitamin D and colorectal cancer

  • 90. Vitamin D in the management of lung cancer: influence of tumor stage, tumor genotype, and treatment modality

  • 91. Vitamin D and prostate cancer

  • 92. Vitamin D and pancreatic cancer

  • 93. Sunlight, skin cancer and vitamin D

  • 94. Vitamin D and antibacterial immunity

  • 95. Vitamin D and antiviral immunity

  • 96. Vitamin D and adaptive immunity in health and disease

  • 97. Vitamin D, microbiota, and inflammatory bowel disease

  • 98. Vitamin D and tuberculosis

  • 99. The role of vitamin D in COVID-19

  • 100. Vitamin D and type 1 diabetes

  • 101. Vitamin D mechanisms of protection in multiple sclerosis

  • 102. Vitamin D and the epidemiology of multiple sclerosis

  • 103. Vitamin D and rheumatoid arthritis

  • 104. Psoriasis and other skin disorders

  • 105. Vitamin D, acute respiratory infection, and Asthma/COPD

  • 106. Vitamin D and acute illness

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