Far fewer health problems from western diet if add Vitamin D (in rats in this study)

Created September 2018

Dietary supplementation of vitamin D prevents the development of western diet-induced metabolic, hepatic and cardiovascular abnormalities in rats.

United European Gastroenterol J. 2018 Aug;6(7):1056-1064. doi: 10.1177/2050640618774140. Epub 2018 May 17.

Mazzone G1, Morisco C 2, Lembo V 1, D'Argenio G 1, D'Armiento M 2, Rossi A 1, Giudice CD 2, Trimarco B2, Caporaso N 1 nicola.caporaso@unina.it , Morisco F 1.

1 Gastroenterology, Department of Clinical Medicine and Surgery, University 'Federico II', Naples, Italy.

2 Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy.

| | | | | | | --- | --- | --- | --- | --- | | | Standard Diet | Western Diet | Western Diet
* Vitamin D | p-value | | Glycaemia | 99 | 139 | 103 | p <0.05 | | HOMA-OR | 6 | 42 | 16 | p <0.05 | --- 1. Cardiovascular category starts with the following {include} --- 1. Overview Liver and vitamin D contains the following summary {include} --- 1. Diabetes category starts with the following {include}

PDF is available free at Sci-Hub  10.1177/2050640618774140

Heart Fibrosis

image

BACKGROUND:

The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.

OBJECTIVE:

To evaluate whether long-term daily vitamin D3 supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency.

METHODS:

Three groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D3, respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method.

RESULTS:

Sixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D3 (p < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, p < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin D3 supplementation.

CONCLUSION:

In animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin D3 shows liver and cardio-protective effects.

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Tags: Cardiovascular Liver