Eyes with poor blood drainage (RVO) have very low levels of vitamin D

Created April 2017

Serum vitamin D levels in Indian patients with retinal venous occlusions

Saudi Journal of Ophthalmology. online 28 March 2017, http://doi.org/10.1016/j.sjopt.2017.03.005

Avadhesh Oli, , D. Joshi

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    BVO                 CRVO                 Normal

1. Vision category starts with the following {include} --- 1. See also VitaminDWiki * Risk of bleeding in the eye (RVO) is 14 X more likely if low vitamin D – meta-analysis July 2024 * Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015 * Suspect that RVO may also be more likely with high blood pressure * Vitamin K2-7 decreases arterial stiffness (cleans arteries) – RCT Feb 2015 * Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015 * Suspect that Vitamin K2 would also reduce RVO 1. See also web * Central Retinal Vein Occlusion Associated With Severe Vitamin D Deficiency April 2016 * The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia 2010, about 4 in 1,000 people - Full free PDF online * Central Retinal Vein Occlusion Clinical Presentation Medscape June 2016 * Central retinal vein occlusion Wikipedia

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Purpose

To estimate serum vitamin D (25 OH D) level in patients of retinal vein occlusion (RVO) and compare it with age-matched controls.

Methods and material

Forty patients above 18 years of age with retinal vein occlusion and forty age-matched controls underwent serum vitamin D (Vit D) level estimation using a standard protocol. Student’s t test was used to analyse differences between the mean of two groups.

Results

The mean age in RVO and control group was 60.25 and 60.73 years respectively. The mean (±SD) level of vitamin D in RVO patients was 13.68 (±4.58) ng/mL (range 5.5–24.8), and the 95% CI of mean was 12.21–15.14 with SD 4.58 while in control group it was 23.03 (±2.89) ng/ml (range 18.4–30.1) with 95% CI of mean being 22.11–23.96 with SD 2.89 (p value of <0.005). While comparing the level of Vitamin D based on type of occlusion the mean level of Vit D in CRVO patients was 15.36 (SD 5.30) and in BRVO it was 12.77 (SD 3.96) which was statistically not significant (p = 0.08). The odds ratio calculated for RVO cases versus controls was 133.33 which was statistically significant (P < 0.05).

Conclusions

There is a paucity of published literature on level of Vit D in RVO. This study shows significantly lower levels of serum vitamin D in Indian patients with retinal vein occlusion as compared to age matched controls. Establishment of this correlation has possible implications for prophylaxis or treatment of RVOs.

Tags: Vision