Dose response equations for Vitamin D

Graph of Predicted vs. observed serum 25-hydroxyvitamin D concentrations.

serum vitamin D ng/ ml in blood = (427.46(1+pigmentation grade)10-2 +(dose IU/day)10-2)/Body massindex,

that is: (430 * square root of (1+pigmentation grade) + square root of IU)/ Body massindex

pigmentation grade: 2 = light, 1= intermediate, 0 = dark),

body mass index = (weight lbs)(703)/(height inches)**2

  • Click here for BMI calculator

  • Equation does not consider other factors which will change change the response:

    • medical problems, supplements, vitamin A, latitude, smoking, how much get from the sun (time in the sun, age, ...__
  • Click here for Smoking decrease vitamin D

  • Equation appears to generally predict response correctly to within +-50%

  • Vitamin D dose-response is not linear – Feb 2011 equation up to perhaps 140 ng

  • Equation is based on data from 15-40 ng - doubt that this equation is correct for 60 ng

    • from: Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults June 2010
  • [tiki-download_file.php?fileId=1204]

Based on 198 people in NE US in Fall and Winter 2009-2010

image

Close up view of the data

image

Need a vitamin D equation to account for:

image

Unhealthy people need even more vitamin D

And - the blood levels vary by 4X between individuals.


See also VitaminDWiki

image

Tags: How much