Diagnosis and treatment of osteopenia – Holick 2010

Rev Endocr Metab Disord. 2010 Dec;11(4):237-51. doi: 10.1007/s11154-010-9154-0.

Karaguzel G1, Holick MF.

A good sign of low vitamin D is when2 out of 3 bones hurt when pressed      (breastbone, left shin, right shin) Want to catch and stop or reverse Osteopenia before it becomes Osteoporosis It is very difficult (impossible?) to reverse Osteoporosis - by then too many "bone bridges" are gone Magnesium is removed by water softeners * "Soft water" is free from dissolved salts of such metals as calcium, iron, or magnesium , which form insoluble deposits such as appear as scale in boilers or soap curds in bathtubs and laundry equipment. * "A typical residential ion-exchange water softener softens hard water by exchanging calcium and magnesium for sodium" * A quick search of the web was unable to find how much Magnesium is removed: 50%, 80 %, 90%? * Reverse osmosis removes 93-99% of all Magnesium and Calcium --- 1. Building bone takes more than just Vitamin D * Adding just vitamin D again failed to add bone density (also need Magnesium, Vitamin K, etc) – RCT Aug 2018 * Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012 * Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012 * Vitamin K and bone – review Oct 2017 * Bone formation in the lab is aided by Vitamin D, Vitamin K1, and Vitamin K2 – meta-analysis Nov 2017 * Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018 --- 1. Supplementing * 4,000 IU of Vitamin D is OK - 19 organizations agree - 2018 * Bulk supplementation of Vitamin D, Magnesium, Zinc, B-12, K2, Boron etc. - lower cost and easier than pills - and Resveratrol * Founder of VitaminDWiki currently take no pills - all bulk powder, <50 cents per day * Consider restoring the Vitamin D levels in days, not months * Can immediate start building bone with Magnesium, Boron, etc. without having to wait for months for the Vitamin D levels to get > 30 ng Magnesium and Vitamin D contains the following summary {include} --- 1. Overview Osteoporosis and vitamin D contains the following summary {include} --- 1. Images from the web image image

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Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis.

By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5.

There are many causes for osteopenia including calcium and vitamin D deficiency and inactivity. Genetics plays an important role in a person's bone mineral density and often Caucasian women with a thin body habitus who are premenopausal are found to have osteopenia.

Correction of calcium and vitamin D deficiency and walking 3 to 5 miles a week can often improve bone density in the hip and spine.

There are a variety of pharmaceutical agents that have been recommended for the treatment of osteopenia and osteoporosis including hormone replacement therapy, selective estrogen receptor modulator therapy, anti-resorptive therapy. In addition patients with osteoporosis who have failed anti-resorptive therapy can have a significant improvement in their bone density with anabolic therapy.