Diabetic Nephropathy – active vitamin D helps

Relationship of Vitamin D with Diabetes Mellitus and Diabetic Nephropathy

Port J Nephrol Hypert 2014; 28(2): 108-118, Advance Access publication 16 June 2014

Ana Paula Silva, Andre Fragoso, Pedro Leao Neves

Department of Nephrology, Hospital de Faro - Centro Hospitalar do Algarve. Faro, Portugal

Diabetic nephropathy (DN) is a major public health problem whose prevalence has been increasing in recent years. It is characterized by a progressive pattern and is associated with high morbidity and mortality rates. Several factors are associated with the onset and progression of DN, such as glycaemic control, hypertension, obesity and inflammation status. In addition, vitamin D also seems to be involved through a pleiotropic regulatory activity/protection with promising applicability, either in prevention or progression of renal disease. The purpose of this review was to summarize the scientific evidence that supports the role of vitamin D in diabetes mellitus and DN.

Notes

Longstanding Diabetes ==> Kidney failure (10% of Type II, 30% of Type1) ==> Diabetic Nephropathy

One type of diabetic nephropathy is peripheral nephropathy,

     which affects such body parts as the feet, legs and hands, thus leading to numbness of feet

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See also VitaminDWiki

• Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019

• Diabetic Neuropathy sometimes can be reversed by vitamin D

• Diabetic neuropathy least likely if have 30-40 ng of vitamin D – Oct 2015

• Diabetic foot ulcer associated with extremely low vitamin D levels – Sept 2013

• Peripheral Neuropathy in type II Diabetes reduced a bit by 50,000 IU weekly of vitamin D – RCT Feb 2015

  Calcitriol (active vitamin D) is very important if poor kidney function

  Calcitriol provides vitamin D to the rest of the body AND treats the kidney

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