Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial
BMC Psychiatry . 2022 Nov 11;22(1):694. doi: 10.1186/s12888-022-04305-3.
Mina Kaviani 1 , Bahareh Nikooyeh 2 , Farnaz Etesam 3 , Siroos Jahangiri Behnagh 4 , Hamed Mohammadi Kangarani 5 , Mohammad Arefi 5 , Parichehreh Yaghmaei 6 , Tirang R Neyestani 7
Background: Both augmented inflammatory reaction and low vitamin D status are associated with depression but the magnitude of their relationships is unclear. This study was, therefore, conducted to evaluate the effects of vitamin D supplementation on serum 25(OH)D concentration, depression severity and some pro-inflammatory biomarkers in patients with mild to moderate depression.
Methods: An 8-week double-blind randomized clinical trial (RCT) was performed on 56 (18-60 yrs) patients with mild to moderate depression, randomly assigned to intervention (50,000 IU cholecalciferol 2wks-1) and control (placebo) groups. Serum 25(OH)D, intact parathyroid hormone (iPTH), interlukin (IL)-1β, IL-6, high-sensitivity C-reactive protein (hs-CRP) and depression severity (Beck Depression Inventory-II) (BDI-II)) were initially and finally assessed.
Results: At the end point, statistically significant changes were observed only in intervention group as compared with controls including increased 25(OH)D concentration (+ 40.83 ± 28.57 vs. + 5.14 ± 23.44 nmol L-1, P < 0.001) and decreased depression severity (-11.75 ± 6.40 vs. -3.61 ± 10.40, P = 0.003). No significant within- or between group differences were observed in serum IL-1β, IL-6 and hs-CRP concentrations.
Conclusion: Increased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks-1) resulted in a significant decrease in BDI-II scores in patients with mild to moderate depression. However, this effect was independent of the serum concentrations of the studied inflammatory biomarkers.
Trial registration: The clinical trial registration code was obtained from the Iranian Registry of Clinical Trials (date of registration: 17/09/2018, registration number: IRCT20170926036425N1) and ClinicalTrials.gov (date of registration: 04/12/2018, registration number: NCT03766074).
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Intervention of Vitamin D for Depression
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Meta-analyses of Vitamin D and Depression
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VitaminDWiki - Depression category contains
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Many other health problems fought by 50,000 IU weekly or biweekly
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Note: Magnesium and Omega-3 work synergistically with Vitamin D - such as reducing depression
studies in both categories Depression and Magnesium
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studies in both categories Depression and Omega-3
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Many otther health problems are now fought by the combo - unware of any depression studies using the combo
Many of the high-dose vitamin D therapies include Magnesium and Omega-
studies in both categories Magnesium and Omega-3
This list is automatically updated
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