COVID and vaccine spikes damage repair of adaptive immune system DNA (in the lab)
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro
by Hui Jiang 1,2,* andYa-Fang Mei 2,*
Viruses 2021, 13(10), 2056; https://doi.org/10.3390/v13102056
1 Department of Molecular Biosciences, The Wenner–Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden
2 Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses ; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear.
Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity.
Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.
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VitaminDWiki - Observations
Previous studies found that COVID-19 infections resulted in delayed and weak adaptive immune responses
This lab study found that the COVID and Vaccine spikes are probably the source of the problem
Wonder if these spike are associated with COVID deaths and long haul
VitaminDWiki - Mortality and Virus studies
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VitaminDWiki - LONG-HAUL in title (17 as of Dec 2021)
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