COVID-19 male mortality increased 3.9 X if low vitamin D – observation

Created November 2020

Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality

Am J Clin Pathol. 2020 Nov 25;aqaa252. doi: 10.1093/ajcp/aqaa252

Dieter De Smet 1, Kristof De Smet 2, Pauline Herroelen 1, Stefaan Gryspeerdt 2, Geert A Martens 1 3 4

Observation in Belgium, March 2020 Note: Belgium is running Clinical Trial 1. 37 below using 100,000 IU of Vitamin D 1. COVID-19 treated by Vitamin D - studies, reports, videos {include} Items in both categories Virus and Mortality are listed here: {category} --- This study was available as a preprint May 16 * Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics preprint May 5. updated May 18 * Vitamin D levels     : all males at same hospital in 2019,            males in 2020 with COVID-19 * image

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Males: Generally Lower Vitamin D levels were associated with worse COVID-10

Note: A few % had high level of vitamin D

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Objectives: Vitamin D deficiency was previously correlated with incidence and severity of coronavirus disease 2019 (COVID-19). We investigated the association between serum 25-hydroxyvitamin D (25(OH)D) level on admission and radiologic stage and outcome of COVID-19 pneumonia.

Methods: A retrospective observational trial was done on 186 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals hospitalized from March 1, 2020, to April 7, 2020, with combined chest computed tomography (CT) and 25(OH)D measurement on admission. Multivariate regression analysis was performed to study if vitamin D deficiency (25(OH)D <20 ng/mL) correlates with survival independently of confounding comorbidities.

Results: Of the patients with COVID-19, 59% were vitamin D deficient on admission: 47% of females and 67% of males. In particular, male patients with COVID-19 showed progressively lower 25(OH)D with advancing radiologic stage, with deficiency rates increasing from 55% in stage 1 to 74% in stage 3.

Vitamin D deficiency on admission was not confounded by

  • age,

  • ethnicity,

  • chronic lung disease,

  • coronary artery disease/hypertension, or

  • diabetes

and was associated with mortality (odds ratio [OR], 3.87 ; 95% confidence interval [CI], 1.30-11.55),

independent of

  • age (OR, 1.09; 95% CI, 1.03-1.14),

  • chronic lung disease (OR, 3.61; 95% CI, 1.18-11.09), and

  • extent of lung damage expressed by chest CT severity score (OR, 1.12; 95% CI, 1.01-1.25).

Conclusions: Low 25(OH)D levels on admission are associated with COVID-19 disease stage and mortality.

Tags: Mortality Virus