Common drugs as vitamin D disruptors – 2020
Journal of Translational Science doi: 10.15761/JTS.1000378
Uwe Gröber AMM - Academy of Micronutrient Medicine, Essen, Germany uwegroeber@gmx.net
In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.
| PXR-Ligands | Examples |
| Antiepileptics | Phenytoin, carbamazepine |
| Antineoplastic drugs | Cyclophophamide, epirubicin, taxol, tamoxifen |
| Antibiotics | Clotrimazole, rifampicin |
| Anti-inflammatory agents | Dexamethasone |
| Antihypertensives | Nifedipine, spironolactone |
| Antiretroviral drugs | Efavirenz, ritonavir, saquinavir |
| Endocrine drugs | Cyproterone acetate |
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This study only looks at only one of the 6 genes that reduce Vitamin D getting to cells
VitaminDWiki - Interactions with Vitamin D contains
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