Cleaning out poor cells (autophagy) is increased by Vitamin D and fasting

Vitamin D in autophagy signaling for health and diseases: Insights on potential mechanisms and future perspectives

Journal of Nutritional Biochemistry 99 (2022) 108841 https://doi.org/10.1016/j.jnutbio.2021.108841

Sujit Kumar Bhutia

Study Table of contents

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Vitamin D regulates the pleiotropic effect to maintain cellular homeostasis and epidemiological evidence establishes an association between vitamin D deficiency and various human diseases. Here, the role of autophagy, the cellular self-degradation process, in vitamin D-dependent function is documented in different cellular settings and discusses the molecular aspects for treating

  • chronic inflammatory,

  • infectious diseases, and

  • cancer.

Vitamin D activates autophagy through a genomic and non-genomic signaling pathway to influence a wide variety of physiological functions of different body organs along with bone health and calcium metabolism. Moreover, it induces autophagy as a protective mechanism to inhibit oxidative stress and apoptosis to regulate cell proliferation, differentiation, and immune modulation. Furthermore, vitamin D and its receptor regulate autophagy signaling to control inflammation and host immunity by activating antimicrobial defense mechanisms. Vitamin D has been revealed as a potent anticancer agent and induces autophagy to increase the response to radiation and chemotherapeutic drugs for potential cancer therapy. Increasing vitamin D levels in the human body through timely exposure to sunlight or vitamin D supplements could activate autophagy as part of the homeostasis mechanism to prevent multiple human diseases and aging-associated dysfunctions.

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Tried vitamin D + water fasting - Great! - Feb 2023

By the founder of VitaminDWiki, Henry Lahore

I have tried fasting many times in my life, but previous fasts only lasted about 1 day

The fasts were stopped because of an extreme lack of energy

In Jan 2023, our son tried water fasts, which he started with a large dose of Vitamin D

His six fasts have been extremely successful

  • felt better,

  • lasted 3-4 days each

  • experience no energy/brain loss during the fast

  • lost about 5 lbs on each fast

  • did not feel especially hungry after the fast AND he kept the weight off (20 lbs so far)

  • felt that his brain was working much better after a fast, especially ones lasting 5 days

I added nanoemulsion vitamin D and ionized Magnesium several times each day during my fasts

I successfully had many 2-3-day water fasts

My results were similar to that of our son

Nanoemulsion Vitamin D may be a substantially better form

Be sure to swish the milliliter of nanoD in your mouth for a minute or two

This gets it directly into the bloodstream without being delayed by the stomach, intestines, lymph (?), liver and kidneys.

Chart of the above is at:
Permanent Weight Loss - lots of Vitamin D then water-fast (2 people so far) - July 2023

  Note: Virtually every cell in your body has the ability to fully process vitamin D


Vitamin D also augments weight loss without fasting

Many studies have found that people who want to lose weight by calorie restriction or exercise have much more success when they add Vitamin D ( weeks or months before starting the weight loss plan unless they start with a loading dose)

Weight loss and Vitamin D - many studies

Have been unable to find anyone on the web who has tried Vitamin D + water fasting

Please email me if you have any data or experience [hlahore@gmail.com]


VitaminDWiki - Fasting and Vitamin D - many studies


Time-Restricted Eating and High-Intensity Interval Training Reduced Fat Feb 2023

Combination of Time-Restricted Eating and HIIT Reduced Blood Sugar, Weight and Visceral Fat in Obese and Overweight Women


VitaminDWiki - Fasting and Vitamin D - many studies


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Tags: Obesity