Chronic Heart Failure – not enough evidence that Vitamin D helps (but lots of evidence for other cardiovascular problems)

Created August 2017

Vitamin D and Heart Failure

Current Heart Failure Reports, pp 1–11, Aug 2017, https://doi.org/10.1007/s11897-017-0355-7

D. Marshall Brinkley, Omair M. Ali, Sandip K. Zalawadiya ,Thomas J. Wang

* Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015 Wonder if the study on this page alos failed to consider dose size * Chronic Heart Failure reduced by 4,000 IU daily for a year – RCT April 2016 * Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017 * Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016 * Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015 * More than 800 mg of Calcium increases Cardiovascular events by 85 percent– Nov 2011 Wonder if the study on this page looked at interaction with Calcium * Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT Feb 2012 1. Cardiovascular category starts with the following {include}

Purpose

Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure.

Recent Findings.

Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive.

Summary

There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure . Prospective trials powered for clinical outcomes are warranted.

Publisher wants $40 for the PDF

Tags: Cardiovascular